3,5-DIFLUORO-2-METHOXYBENZALDEHYDE

Base Information

• Chemical Name: 3,5-DIFLUORO-2-METHOXYBENZALDEHYDE
• CAS No.: 131782-50-8
• Molecular Formula: C8H6F2O2
• Molecular Weight: 172.131
• Hs Code.: 2913000090
• Mol file: 131782-50-8.mol

Synonyms:PC1129;JRD-1722;Benzaldehyde,3,5-difluoro-2-methoxy;3,5-difluoro-2-methoxy-benzaldehyde;

Chemical Property of 3,5-DIFLUORO-2-METHOXYBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0312mmHg at 25°C
• Boiling Point: 243.9oC at 760 mmHg
• Flash Point: 98.5oC
• PSA: 26.30000
• Density: 1.289g/cm3
• LogP: 1.78590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

97% ^*data from raw suppliers

3,5-Difluoro-2-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 3,5-DIFLUORO-2-METHOXYBENZALDEHYDE

There total 5 articles about 3,5-DIFLUORO-2-METHOXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluorophenol (367-27-1) → 3,5-difluoro-2-methoxybenzaldehyde (131782-50-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / K₂CO₃ / acetone / 48 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h

4: 2,2,2-trifluoroethanol, tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / -78 - 20 °C

With n-butyllithium; 2,2,2-trifluoroethanol; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1021/jm00076a024

Reference yield:

2,4-difluoro-1-methoxybenzene (452-10-8) → 3,5-difluoro-2-methoxybenzaldehyde (131782-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h

3: 2,2,2-trifluoroethanol, tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / -78 - 20 °C

With n-butyllithium; 2,2,2-trifluoroethanol; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/jm00076a024

Reference yield:

2-(trimethylsilyl)-4-methoxy-1,3-difluorobenzene (114636-02-1) → 3,5-difluoro-2-methoxybenzaldehyde (131782-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 3 h, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 1 h

2: 2,2,2-trifluoroethanol, tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / -78 - 20 °C

With n-butyllithium; 2,2,2-trifluoroethanol; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/jm00076a024

upstream raw materials:

2,4-difluorophenol

2,4-difluoro-1-methoxybenzene

2-(trimethylsilyl)-4-methoxy-1,3-difluorobenzene

Downstream raw materials:

3,5-difluoro-2-methoxyphenol

(3,5-difluoro-2-methoxy-phenyl)-methanol

N-(3,5-difluoro-2-methoxybenzylidene)-4-methylbenzenesulfonamide

2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole