Technology Process of o-<(8-bromo-1-naphthyl)methyl>acetophenone
There total 7 articles about o-<(8-bromo-1-naphthyl)methyl>acetophenone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: n-butyllithium, conc. H2SO4
2: HI, H3PO2 / acetic acid; acetic anhydride / 5 h / Heating
3: thionyl chloride, DMF / CH2Cl2 / 18 h / Heating
4: cuprous iodide / -78 deg C, 25 min, ether
With
copper(l) iodide; n-butyllithium; thionyl chloride; sulfuric acid; hydrogen iodide; hypophosphorous acid; N,N-dimethyl-formamide;
In
dichloromethane; acetic anhydride; acetic acid;
DOI:10.1021/jo00165a029
- Guidance literature:
-
Multi-step reaction with 6 steps
1: trimethyl borate, BH3*Me2S / tetrahydrofuran / 2.5 h / Heating
2: 89 percent / 1.) N-chlorosuccinimide, dimethyl sulfide, 2.) triethylamine / toluene / 1.) -30+/-5 deg C, 30 min; 4 h, -25 deg C, 2.) RT
3: n-butyllithium, conc. H2SO4
4: HI, H3PO2 / acetic acid; acetic anhydride / 5 h / Heating
5: thionyl chloride, DMF / CH2Cl2 / 18 h / Heating
6: cuprous iodide / -78 deg C, 25 min, ether
With
N-chloro-succinimide; copper(l) iodide; n-butyllithium; thionyl chloride; dimethylsulfide; Trimethyl borate; dimethylsulfide borane complex; sulfuric acid; hydrogen iodide; hypophosphorous acid; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; acetic anhydride; acetic acid; toluene;
DOI:10.1021/jo00165a029
- Guidance literature:
-
Multi-step reaction with 4 steps
1: n-butyllithium, conc. H2SO4
2: HI, H3PO2 / acetic acid; acetic anhydride / 5 h / Heating
3: thionyl chloride, DMF / CH2Cl2 / 18 h / Heating
4: cuprous iodide / -78 deg C, 25 min, ether
With
copper(l) iodide; n-butyllithium; thionyl chloride; sulfuric acid; hydrogen iodide; hypophosphorous acid; N,N-dimethyl-formamide;
In
dichloromethane; acetic anhydride; acetic acid;
DOI:10.1021/jo00165a029
