(R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane

Base Information

Chemical Name:(R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane
CAS No.:156727-89-8
Molecular Formula:C₃₄H₄₄N₂O₉
Molecular Weight:624.731
Hs Code.:

(R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-<N-(2,2-diethoxyethyl)-N-(3,4,5-trimethoxybenzoyl)>aminopropane

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Chemical Property of (R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane

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Technology Process of (R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane

There total 6 articles about (R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58578-42-0,98757-96-1,58577-90-5
(R)-benzyl 1-(benzyloxy)-3-hydroxypropan-2-ylcarbamate

: 156727-89-8
(R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h / -10 °C

2: K₂CO₃, 18-crown-6 / dimethylformamide / 3 h / 70 °C

3: dimethylformamide / 3 h / 70 °C

4: Et₃N / dimethylformamide / 0 °C

With 18-crown-6 ether; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.551

Reference yield:

: 20806-43-3
Z-Ser(Bzl)-OH

: 156727-89-8
(R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane

Guidance literature:: Multi-step reaction with 6 steps

1: dicyclohexylcarbodiimide / tetrahydrofuran / 1 h / Ambient temperature

2: NaBH₄ / tetrahydrofuran; methanol; H₂O / 2 h / -10 °C

3: Et₃N / CH₂Cl₂ / 1 h / -10 °C

4: K₂CO₃, 18-crown-6 / dimethylformamide / 3 h / 70 °C

5: dimethylformamide / 3 h / 70 °C

6: Et₃N / dimethylformamide / 0 °C

With sodium tetrahydroborate; 18-crown-6 ether; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.551

Reference yield:

: 645-36-3
2,2-diethoxy-ethanamine

: 156727-89-8
(R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylformamide / 3 h / 70 °C

2: Et₃N / dimethylformamide / 0 °C

With triethylamine; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.551