Ac-Ala₃-PheCH₃

Base Information

• Chemical Name: Ac-Ala₃-PheCH₃
• CAS No.: 90427-67-1
• Molecular Formula: C₂₁H₃₀N₄O₅
• Molecular Weight: 418.493
• Mol file: 90427-67-1.mol

Synonyms:

Chemical Property of Ac-Ala₃-PheCH₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ac-Ala₃-PheCH₃

There total 5 articles about Ac-Ala₃-PheCH₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

acetic anhydride (108-24-7) + Ala3-PheCH3, HBr (90427-76-2) → Ac-Ala3-PheCH3 (90427-67-1)

Guidance literature:

In pyridine; for 2h; Ambient temperature;

Reference yield:

(S)-3-(N-(benzyloxycarbonyl)amino)-4-phenyl-2-butanone (111491-96-4) → Ac-Ala3-PheCH3 (90427-67-1)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂, 2 N HCl / Pd

2: 98 percent / NEt₃, ethyl chlorocarbonate / dimethylformamide; tetrahydrofuran

3: HBr / acetic acid

4: 60 percent / pyridine / 2 h / Ambient temperature

With hydrogenchloride; hydrogen bromide; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium; In tetrahydrofuran; pyridine; acetic acid; N,N-dimethyl-formamide;

Reference yield:

Nα-benzyloxycarbobyl-L-alanyl-L-alanyl-L-alanine (13585-98-3) → Ac-Ala3-PheCH3 (90427-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / NEt₃, ethyl chlorocarbonate / dimethylformamide; tetrahydrofuran

2: HBr / acetic acid

3: 60 percent / pyridine / 2 h / Ambient temperature

With hydrogen bromide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; pyridine; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

acetic anhydride

Ala₃-PheCH₃, HBr

N^α-benzyloxycarbobyl-L-alanyl-L-alanyl-L-alanine

Z-Ala₂-Ala-PheCH₃