1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(1,1-dimethyl-heptyl)-2-{(1R,2R)-2-isopropenyl-5-[1-methoxy-meth-(Z)-ylidene]-cyclohexyl}-benzene

Base Information

• Chemical Name: 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(1,1-dimethyl-heptyl)-2-{(1R,2R)-2-isopropenyl-5-[1-methoxy-meth-(Z)-ylidene]-cyclohexyl}-benzene
• CAS No.: 213915-74-3
• Molecular Formula: C₃₈H₆₈O₃Si₂
• Molecular Weight: 629.127
• Mol file: 213915-74-3.mol

Synonyms:

Chemical Property of 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(1,1-dimethyl-heptyl)-2-{(1R,2R)-2-isopropenyl-5-[1-methoxy-meth-(Z)-ylidene]-cyclohexyl}-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(1,1-dimethyl-heptyl)-2-{(1R,2R)-2-isopropenyl-5-[1-methoxy-meth-(Z)-ylidene]-cyclohexyl}-benzene

There total 1 articles about 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(1,1-dimethyl-heptyl)-2-{(1R,2R)-2-isopropenyl-5-[1-methoxy-meth-(Z)-ylidene]-cyclohexyl}-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,4R,5R)-4-(2,6-dihydroxy-4-(2-methyloctan-2-yl)phenyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-one (182509-23-5) → 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(1,1-dimethyl-heptyl)-2-{(1R,2R)-2-isopropenyl-5-[1-methoxy-meth-(Z)-ylidene]-cyclohexyl}-benzene (213915-74-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / imidazole, DMAP / dimethylformamide / 36 h / Ambient temperature

2: 1.) TMSI, t-BuOH, 2.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) CCl₄, 0 deg C, 1.5 h, 2.) C₆H₆, 50 deg C, 3 h

3: 1.) sodium tert-amylate / 1.) C₆H₆, RT, 15 min, 2.) C₆H₆, 70 deg C, 3 h

With 1H-imidazole; dmap; trimethylsilyl iodide; sodium tert-pentoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butyl alcohol; In N,N-dimethyl-formamide;

DOI:10.1021/jm960677q

Reference yield:

1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(1,1-dimethyl-heptyl)-2-{(1R,2R)-2-isopropenyl-5-[1-methoxy-meth-(Z)-ylidene]-cyclohexyl}-benzene (213915-74-3) → 1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-2-[(1R,2R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropenyl-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene (213915-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. CCl₃CO₂H / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 72 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

3: 100 percent / imidazole / dimethylformamide / 17 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; trichloroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm960677q

Reference yield:

1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(1,1-dimethyl-heptyl)-2-{(1R,2R)-2-isopropenyl-5-[1-methoxy-meth-(Z)-ylidene]-cyclohexyl}-benzene (213915-74-3) → 2-[(1R,2R,4R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexyl]-prop-2-en-1-ol (213915-78-7)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. CCl₃CO₂H / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 72 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

3: 100 percent / imidazole / dimethylformamide / 17 h / Ambient temperature

4: SeO₂, salicylic acid, t-BuOOH / CH₂Cl₂ / 2 h / Ambient temperature

5: NaBH₄ / methanol / 0.5 h / Ambient temperature

With 1H-imidazole; tert.-butylhydroperoxide; sodium tetrahydroborate; selenium(IV) oxide; salicylic acid; trichloroacetic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm960677q

upstream raw materials:

(1R,4R,5R)-4-(2,6-dihydroxy-4-(2-methyloctan-2-yl)phenyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-one

Downstream raw materials:

(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexanecarbaldehyde

5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5R)-5-hydroxymethyl-2-(1-hydroxymethyl-vinyl)-cyclohexyl]-benzene-1,3-diol

(6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6-(2-iodo-ethyl)-6-methyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-1-ol

2-[(1R,2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2-(3-hydroxy-1-methylene-propyl)-cyclohexyl]-5-(1,1-dimethyl-heptyl)-benzene-1,3-diol