2-[2-(2-Naphthalenyl)ethoxy]adenosine

Base Information

• Chemical Name: 2-[2-(2-Naphthalenyl)ethoxy]adenosine
• CAS No.: 131865-99-1
• Molecular Formula: C22H23N5O5
• Molecular Weight: 437.44900
• Mol file: 131865-99-1.mol

Synonyms:(2R,3S,5R)-2-[6-amino-2-(2-naphthalen-2-ylethoxy)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol;

Chemical Property of 2-[2-(2-Naphthalenyl)ethoxy]adenosine

Chemical Property:

• PSA: 148.77000
• LogP: 1.37590

Purity/Quality:

97% ^*data from raw suppliers

2-[2-(2-Naphthalenyl)ethoxy]adenosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(2-Naphthalenyl)ethoxy]adenosine

There total 3 articles about 2-[2-(2-Naphthalenyl)ethoxy]adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

naphthalen-2-ethanol (1485-07-0) → 2-[2-(2-Naphthylethoxy)adenosine] (131865-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) 1,2-dimethoxyethane, 10 deg C, 15 min, 2.) 1,2-dimethoxyethane, reflux, 5 days

2: acetic acid, formic acid / H₂O / 2 h / Heating

With n-butyllithium; formic acid; acetic acid; In water;

DOI:10.1021/jm00108a015

Reference yield:

{(3aR,4R,6R,6aR)-6-[6-Amino-2-(2-naphthalen-2-yl-ethoxy)-purin-9-yl]-2-ethoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol → 2-[2-(2-Naphthylethoxy)adenosine] (131865-99-1)

Guidance literature:

With formic acid; acetic acid; In water; for 2h; Yield given; Heating;

DOI:10.1021/jm00108a015

Reference yield:

2-chloro-2',3'-O-(ethoxymethylidene) adenosine (56720-43-5) → 2-[2-(2-Naphthylethoxy)adenosine] (131865-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) 1,2-dimethoxyethane, 10 deg C, 15 min, 2.) 1,2-dimethoxyethane, reflux, 5 days

2: acetic acid, formic acid / H₂O / 2 h / Heating

With n-butyllithium; formic acid; acetic acid; In water;

DOI:10.1021/jm00108a015

upstream raw materials:

2-chloro-2',3'-O-(ethoxymethylidene) adenosine

naphthalen-2-ethanol

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