1,4-Benzenedicarboxylic acid, monomethyl ester, hydrazide

Base Information

• Chemical Name: 1,4-Benzenedicarboxylic acid, monomethyl ester, hydrazide
• CAS No.: 13188-55-1
• Molecular Formula: C9H10N2O3
• Molecular Weight: 194.19
• Mol file: 13188-55-1.mol

Synonyms:

Chemical Property of 1,4-Benzenedicarboxylic acid, monomethyl ester, hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Benzenedicarboxylic acid, monomethyl ester, hydrazide

There total 8 articles about 1,4-Benzenedicarboxylic acid, monomethyl ester, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 2-(4-(methoxycarbonyl)benzoyl)hydrazinecarboxylate → 4-hydrazinocarbonylbenzoic acid methyl ester (13188-55-1)

Guidance literature:

With methanol; acetyl chloride; at 0 - 20 ℃; for 20h;

Reference yield: 70.0%

Monomethyl terephthalate (1679-64-7) → 4-hydrazinocarbonylbenzoic acid methyl ester (13188-55-1)

Guidance literature:

With fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate;

Reference yield: 70.0%

Monomethyl terephthalate (1679-64-7) + N,N,N',N'-tetramethylformamidinium hexafluorophosphate → 4-hydrazinocarbonylbenzoic acid methyl ester (13188-55-1)

Guidance literature:

upstream raw materials:

1,4-benzenedicarboxylic acid dimethyl ester

4-Methoxycarbonylbenzoyl chloride

Monomethyl terephthalate

(carbonic acid ethyl ester)-(terephthalic acid methyl ester)-anhydride

Downstream raw materials:

4-(1,3,4-oxadiazol-2-yl)benzoic acid methyl ester

C₂₄H₂₃N₃O₆

C₂₂H₁₇N₃O₅

C₂₄H₂₁N₃O₅

Refernces

• 1、 -. "AROMATIC RING OR HETEROAROMATIC RING COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF". Paragraph 0094; 0098; 0134; 0136. . Retrieved 2021/12/18.
• 2、 Zhang, Lei,Shi, Lei,Soars, Shafer Myers,Kamps, Joshua,Yin, Hang. "Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties". . p. 5881 - 5899. Retrieved 2018/06/13.