N,N'-Bis(p-methoxycarbonylbenzoyl)hydrazine

Base Information

• Chemical Name: N,N'-Bis(p-methoxycarbonylbenzoyl)hydrazine
• CAS No.: 24000-79-1
• Molecular Formula: C18H16 N2 O6
• Molecular Weight: 356.335
• DSSTox Substance ID: DTXSID0066951
• Nikkaji Number: J37.600K
• Wikidata: Q81993530
• Mol file: 24000-79-1.mol

Synonyms:N,N'-Bis(p-methoxycarbonylbenzoyl)hydrazine;24000-79-1;1,4-Benzenedicarboxylic acid, monomethyl ester, 2-[4-(methoxycarbonyl)benzoyl]hydrazide;1,4-Benzenedicarboxylic acid, 1-methyl ester, 4-(2-(4-(methoxycarbonyl)benzoyl)hydrazide);1,4-Benzenedicarboxylic acid, monomethyl ester, 2-(4-(methoxycarbonyl)benzoyl)hydrazide;DTXSID0066951;SCHEMBL11515705;C22H27N2O.I;C22-H27-N2-O.I;1,2-di(4-Carbomethoxybenzoyl)hydrazine;1,2-Bis(4-methoxycarbonylbenzoyl)hydrazine

Chemical Property of N,N'-Bis(p-methoxycarbonylbenzoyl)hydrazine

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 356.10083623
• Heavy Atom Count: 26
• Complexity: 486

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)C(=O)OC

Technology Process of N,N'-Bis(p-methoxycarbonylbenzoyl)hydrazine

There total 3 articles about N,N'-Bis(p-methoxycarbonylbenzoyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-Methoxycarbonylbenzoyl chloride (7377-26-6) → bis(4-methoxycarbonylbenzoyl)hydrazine (24000-79-1)

Guidance literature:

With pyridine; hydrazine hydrate; In tetrahydrofuran; at 0 ℃;

DOI:10.1246/cl.170970

Reference yield:

1,4-benzenedicarboxylic acid dimethyl ester (120-61-6) → bis(4-methoxycarbonylbenzoyl)hydrazine (24000-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 6 h / Heating

2: tetrahydrofuran; pyridine / 6 h / 20 °C

With hydrazine hydrate; In tetrahydrofuran; pyridine; methanol;

DOI:10.1107/S0108270103021413

Reference yield:

4-hydrazinocarbonylbenzoic acid methyl ester (13188-55-1) + 4-Methoxycarbonylbenzoyl chloride (7377-26-6) → bis(4-methoxycarbonylbenzoyl)hydrazine (24000-79-1)

Guidance literature:

In tetrahydrofuran; pyridine; at 20 ℃; for 6h;

DOI:10.1107/S0108270103021413

upstream raw materials:

4-hydrazinocarbonylbenzoic acid methyl ester

4-Methoxycarbonylbenzoyl chloride

1,4-benzenedicarboxylic acid dimethyl ester

Downstream raw materials:

2,5-bis-(4-methoxycarbonylphenyl)-1,3,4,-oxadiazole