Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2'-methoxy-6-methyl-biphenyl-2-ylmethyl ester
There total 11 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2'-methoxy-6-methyl-biphenyl-2-ylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, 22 h; 2.) 1,2-dichloroethane, 24 h, reflux
2: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h
3: 1 M DIBAL / diethyl ether / Ambient temperature
4: tetrahydrofuran / 12 h / Ambient temperature
5: N-chlorosuccinimide / CH2Cl2 / 0.25 h
6: potassium superoxide / 18-crown-6 / diethyl ether / Ambient temperature
7: 59 percent / oxalic acid / pentane / 12 h / Ambient temperature
8: NaBH4 / ethanol / 0.5 h
9: pyridine / CCl4 / 12 h / Ambient temperature
With
pyridine; potassium superoxide; sodium tetrahydroborate; N-chloro-succinimide; triethyloxonium fluoroborate; oxalic acid; diisobutylaluminium hydride; magnesium;
18-crown-6 ether;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; dichloromethane; pentane;
DOI:10.1021/ja00289a023
- Guidance literature:
-
Multi-step reaction with 11 steps
1: oxalyl chloride / CH2Cl2 / 14 h
2: 30 percent NH4OH
3: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, 22 h; 2.) 1,2-dichloroethane, 24 h, reflux
4: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h
5: 1 M DIBAL / diethyl ether / Ambient temperature
6: tetrahydrofuran / 12 h / Ambient temperature
7: N-chlorosuccinimide / CH2Cl2 / 0.25 h
8: potassium superoxide / 18-crown-6 / diethyl ether / Ambient temperature
9: 59 percent / oxalic acid / pentane / 12 h / Ambient temperature
10: NaBH4 / ethanol / 0.5 h
11: pyridine / CCl4 / 12 h / Ambient temperature
With
pyridine; potassium superoxide; ammonium hydroxide; sodium tetrahydroborate; N-chloro-succinimide; oxalyl dichloride; triethyloxonium fluoroborate; oxalic acid; diisobutylaluminium hydride; magnesium;
18-crown-6 ether;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; dichloromethane; pentane;
DOI:10.1021/ja00289a023
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 30 percent NH4OH
2: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, 22 h; 2.) 1,2-dichloroethane, 24 h, reflux
3: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h
4: 1 M DIBAL / diethyl ether / Ambient temperature
5: tetrahydrofuran / 12 h / Ambient temperature
6: N-chlorosuccinimide / CH2Cl2 / 0.25 h
7: potassium superoxide / 18-crown-6 / diethyl ether / Ambient temperature
8: 59 percent / oxalic acid / pentane / 12 h / Ambient temperature
9: NaBH4 / ethanol / 0.5 h
10: pyridine / CCl4 / 12 h / Ambient temperature
With
pyridine; potassium superoxide; ammonium hydroxide; sodium tetrahydroborate; N-chloro-succinimide; triethyloxonium fluoroborate; oxalic acid; diisobutylaluminium hydride; magnesium;
18-crown-6 ether;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; dichloromethane; pentane;
DOI:10.1021/ja00289a023
