26507-91-5

Basic information

• Product Name: 2-METHOXY-3-METHYLBENZOIC ACID
• Synonyms: ASISCHEM Z74673;3-METHYL-O-ANISIC ACID;AKOS BB-7897;2-METHOXY-3-METHYLBENZOIC ACID;2-METHOXY-M-TOLUIC ACID;2-methoxy-3-methylbenzoic acid(SALTDATA: FREE);Methoxyl-m-toluic acid
• CAS NO: 26507-91-5
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 26507-91-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 83 °C
• Boiling Point: 286.8 °C at 760 mmHg
• Flash Point: 114.9 °C
• Appearance: /
• Density: 1.168 g/cm³
• Vapor Pressure: 0.0012mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.16±0.10(Predicted)
• CAS DataBase Reference: 2-METHOXY-3-METHYLBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-3-METHYLBENZOIC ACID(26507-91-5)
• EPA Substance Registry System: 2-METHOXY-3-METHYLBENZOIC ACID(26507-91-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 26507-91-5(Hazardous Substances Data)

Usage

General Description

2-Methoxy-3-methylbenzoic acid, also known as guaiacol-3-carboxylic acid, is a chemical compound with the molecular formula C9H10O3. It is a derivative of benzoic acid, with a methoxy group and a methyl group attached to the benzene ring. 2-Methoxy-3-methylbenzoic acid is commonly used as a flavoring agent in the food industry and as a fragrance ingredient in the cosmetics and personal care products industry. It is also used in organic synthesis and as a starting material for the production of pharmaceuticals and other fine chemicals. 2-Methoxy-3-methylbenzoic acid is a white to off-white crystalline solid with a slightly sweet, phenolic odor. It is considered to be relatively stable under normal conditions and is not known to pose significant health hazards.

InChI:InChI=1/C9H10O3/c1-6-4-3-5-7(9(10)11)8(6)12-2/h3-5H,1-2H3,(H,10,11)

Upstream product

• 142-82-5 n-heptane 
• 578-58-5 2-methylmethoxybenzene 
• 1822-71-5 n-pentylsodium 
• 52239-62-0 methyl 2-methoxy-3-methylbenzoate 
• 188852-08-6 (2-methoxy-3-methyl-phenyl)-acetone 
• 109-66-0 pentane 
• 920-36-5 (2-methylpropyl)lithium 
• 579-75-9 2-Methoxybenzoic acid 
• 74-88-4 methyl iodide 
• 83-40-9 3-methylsalicylic acid 
• 288154-71-2 2-methoxy-3-methylbenzhydrazide 
• 1178514-37-8 C₁₁H₁₄O₄ 
• 7440-44-0 pyrographite 
• 859330-53-3 2-methoxy-1-methyl-3-(prop-1-en-2-yl)benzene 

Downstream Products

• 1951-38-8 2-methoxyisophthalic acid 
• 22256-43-5 2-methoxy-3-methylbenzoyl chloride 
• 854633-33-3 2-methoxy-3-methyl-benzoic acid anilide 
• 90919-44-1 2-Methoxy-3-methyl-5-chlormethylbenzoesaeure 
• 4072-08-6 (2-hydroxy-3-methylphenyl)(phenyl)methanone 
• 4072-09-7 2-methoxy-3-methyl-benzophenone 
• 134268-00-1 7-methyl-3-phenyldihydrobenzofuran 
• 134268-28-3 2-methoxy-3-methylbenzophenone hydrazone 
• 134268-06-7 2-methoxy-3-methylphenyl(phenyl)methyl methyl ether 
• 134267-92-8 2-methoxy-3-methylphenyl(phenyl)diazomethane 
• 134268-13-6 3-(2,5-dimethoxyphenyl)-7-methyldihydrobenzofuran 
• 134268-32-9 2,2',5'-trimethoxy-3-methylbenzophenone hydrazone 
• 134268-21-6 2,5-dimethylphenyl(2-methoxy-3-methylphenyl)methyl methyl ether 
• 134267-96-2 2,5-dimethoxyphenyl(2'-methoxy-3'-methylphenyl)diazomethane 

Relevant articles and documents

Fluorescent macrocyclic chemosensor for Zn(II) detection at alkaline pH values

The new macrocyclic ligand L (28,29-dimethoxy-27-oxa-8,11,14,17,25,26-hexaazatetracyclo[22.2.1.1(2,6).1(19,23)]nonacosa-2,4,6(28),19,21,23(29),24,26(1)-octaene) has been synthesised. It contains a tetramine chain and the 2,5-bis(2-methoxy-3-metyl-phenyl)-

Regiodivergent Iodocyclizations for the Highly Diastereoselective Synthesis of syn - And anti -Hydroxyl-Isochromanones and -Isobenzofuranones: Concise Synthesis of the Isochromanone Core of the Ajudazols

An efficient synthetic strategy to access hydroxyl-isochromanone and -isobenzofurans from readily available joint alkene precursors by a regiodivergent one-pot iodocyclization-substitution tandem process is reported. The cyclizations proceed with excellen

Benzylic hydroxylation of aromatic compounds by P450 BM3

Cytochrome P450 BM3 monooxygenase from Bacillus megaterium and its variants are promising catalysts for organic synthesis. Aiming at the identification of variants for selective hydroxylation of functionalised aromatic compounds, the double mutant F87A L188C showed remarkably improved catalytic activity towards a set of tested toluene derivatives. The apparent catalytic efficiency of this variant towards the model substrate methyl 2-methoxy-3-methylbenzoate was 63.6 s-1 M-1, which is 535-fold higher compared to that of wild-type BM3. Furthermore, the double mutant selectively catalysed the benzylic hydroxylation of numerous toluene derivatives, especially in the presence of carbonyl- or carboxyl-functions that are directly attached to the aromatic ring. Preparative scale conversion resulted in efficient production of methyl 3-(hydroxymethyl)-2-methoxybenzoate (73% yield) which proved that F87A L188C is a suitable, efficient and sustainable catalyst for the introduction of benzylic hydroxyl groups in general.