Diisopropyl-phosphoramidous acid benzyl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Diisopropyl-phosphoramidous acid benzyl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
• CAS No.: 103411-67-2
• Molecular Formula: C₄₄H₅₂N₃O₈P
• Molecular Weight: 781.886

Synonyms:

Chemical Property of Diisopropyl-phosphoramidous acid benzyl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diisopropyl-phosphoramidous acid benzyl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 2 articles about Diisopropyl-phosphoramidous acid benzyl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diisopropylamine (108-18-9) → Diisopropyl-phosphoramidous acid benzyl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (103411-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / PCl₃ / diethyl ether / 1.) -10 grad C, 2.5 h, 2.) room temperature, 1 h

2: 1.) isopropylethylamine / 1.) CH₂Cl₂, -10 grad C, 30 min, 2.) CH₂Cl₂, 30 min

With N-isopropylethylamine; phosphorus trichloride; In diethyl ether;

DOI:10.1016/S0040-4039(00)83976-3

Reference yield:

N,N-diisopropylphosphoramide dichloride (921-26-6) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + benzyl alcohol (100-51-6,185532-71-2) → Diisopropyl-phosphoramidous acid benzyl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (103411-67-2)

Guidance literature:

With N-isopropylethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, -10 grad C, 30 min, 2.) CH₂Cl₂, 30 min;

DOI:10.1016/S0040-4039(00)83976-3

upstream raw materials:

N,N-diisopropylphosphoramide dichloride

5'-O-(4-4'-dimethoxytrityl)thymidine

benzyl alcohol

diisopropylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

✦Write with AI

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 103411-67-2 Diisopropyl-phosphoramidous acid benzyl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send