(4-{2-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetic acid tert-butyl ester

Base Information

Chemical Name:(4-{2-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetic acid tert-butyl ester
CAS No.:437756-13-3
Molecular Formula:C₃₇H₅₃N₃O₉Si
Molecular Weight:711.928
Hs Code.:

(4-{2-[2-(1-{[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetic acid <i>tert</i>-butyl ester

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Chemical Property of (4-{2-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetic acid tert-butyl ester

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Technology Process of (4-{2-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetic acid tert-butyl ester

There total 7 articles about (4-{2-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 437756-13-3
(4-{2-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: DMAP; Et₃N / CH₂Cl₂

2: Des-Martin periodinane / CH₂Cl₂

3: H₂ / Pd(OH)2 / ethyl acetate

4: WSC; pyridine

5: H₂ / Pd(OH)2 / ethyl acetate

6: WSC; pyridine

With pyridine; dmap; hydrogen; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium dihydroxide; In dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(01)00797-1

Reference yield:

: 437756-10-0
2-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-3-methyl-butan-1-ol

: 437756-13-3
(4-{2-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: WSC; pyridine

2: H₂ / Pd(OH)2 / ethyl acetate

3: WSC; pyridine

With pyridine; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In ethyl acetate;
DOI:10.1016/S0960-894X(01)00797-1

Reference yield:

: 437755-82-3
{(S)-1-[Hydroxy-(4-hydroxy-benzooxazol-2-yl)-methyl]-2-methyl-propyl}-carbamic acid benzyl ester

: 437756-13-3
(4-{2-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: DMAP; Et₃N / CH₂Cl₂

2: Des-Martin periodinane / CH₂Cl₂

3: H₂ / Pd(OH)2 / ethyl acetate

4: WSC; pyridine

5: H₂ / Pd(OH)2 / ethyl acetate

6: WSC; pyridine

With pyridine; dmap; hydrogen; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium dihydroxide; In dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(01)00797-1