9(S)-<glycyl>amino>erythromycin

Base Information

Chemical Name:9(S)-<glycyl>amino>erythromycin
CAS No.:121329-80-4
Molecular Formula:C₅₀H₈₄N₄O₁₈
Molecular Weight:1029.23
Hs Code.:

9(S)-<<N-<4-(p-nitroguaiacoxy)butyryl>glycyl>amino>erythromycin

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9(S)-<glycyl>amino>erythromycin

Chemical Property:

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Technology Process of 9(S)-<glycyl>amino>erythromycin

There total 4 articles about 9(S)-<glycyl>amino>erythromycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121329-76-8
4-(p-nitroguaiacoxy)butanenitrile

: 121329-80-4
9(S)-<glycyl>amino>erythromycin

Guidance literature:: Multi-step reaction with 4 steps

1: 1) conc. H₂SO₄, 2) 1 N HCl / 1) room temperature, 48 h, 2) reflux, 15 h

2: dicyclohexylcarbodiimide

3: 5percent NaHCO₃ / 1,2-dimethoxy-ethane / 48 h / Ambient temperature

4: 1) N-hydroxysuccinimide, N,N-dicyclohexylcarbodiimide / 1) dimethoxyethane, room temperature, 15 h, 2) room temperature, 10 h

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; sulfuric acid; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane;
DOI:10.1021/jm00129a027

Reference yield:

: 121329-77-9
4-(2-methoxy-4-nitrophenoxy)butanoic acid

: 121329-80-4
9(S)-<glycyl>amino>erythromycin

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide

2: 5percent NaHCO₃ / 1,2-dimethoxy-ethane / 48 h / Ambient temperature

3: 1) N-hydroxysuccinimide, N,N-dicyclohexylcarbodiimide / 1) dimethoxyethane, room temperature, 15 h, 2) room temperature, 10 h

With 1-hydroxy-pyrrolidine-2,5-dione; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane;
DOI:10.1021/jm00129a027

Reference yield:

: 111621-31-9
4-(2-Methoxy-4-nitro-phenoxy)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

: 121329-80-4
9(S)-<glycyl>amino>erythromycin

Guidance literature:: Multi-step reaction with 2 steps

1: 5percent NaHCO₃ / 1,2-dimethoxy-ethane / 48 h / Ambient temperature

2: 1) N-hydroxysuccinimide, N,N-dicyclohexylcarbodiimide / 1) dimethoxyethane, room temperature, 15 h, 2) room temperature, 10 h

With 1-hydroxy-pyrrolidine-2,5-dione; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane;
DOI:10.1021/jm00129a027