(S)-2-benzyl-butan-1,4-diol

Base Information

• Chemical Name: (S)-2-benzyl-butan-1,4-diol
• CAS No.: 190185-60-5
• Molecular Formula: C₁₁H₁₆O₂
• Molecular Weight: 180.247
• Mol file: 190185-60-5.mol

Synonyms:

Chemical Property of (S)-2-benzyl-butan-1,4-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-benzyl-butan-1,4-diol

There total 4 articles about (S)-2-benzyl-butan-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-fumaroyldi<(2R)-bornane-10,2-sultam> (123191-44-6) + benzylmagnesium chloride (6921-34-2) → (S)-2-benzyl-butan-1,4-diol (190185-60-5) + (R)-2-benzyl-butan-1,4-diol (281214-25-3)

Guidance literature:

N,N'-fumaroyldi<(2R)-bornane-10,2-sultam>; benzylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 3h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3h; Title compound not separated from byproducts;

DOI:10.1016/j.tetasy.2003.12.010

Reference yield:

2-benzylbut-2-ene-1,4-diol (421598-72-3) → (S)-2-benzyl-butan-1,4-diol (190185-60-5) + (R)-2-benzyl-butan-1,4-diol (281214-25-3)

Guidance literature:

With hydrogen; [Ir(COD)(PHOX)]BARF; In dichloromethane; for 2h; under 75006 Torr; Further Variations:; Catalysts; Pressures; Solvents; reaction time; Product distribution;

DOI:10.1055/s-2002-19339

Reference yield:

(2S)-benzylsuccinic acid (3972-36-9,884-33-3) → (S)-2-benzyl-butan-1,4-diol (190185-60-5)

Guidance literature:

With borane-THF;

DOI:10.1016/S0040-4039(99)00824-2

upstream raw materials:

3-benzyl-cyclobutanone

(2S)-benzylsuccinic acid

2-benzylbut-2-ene-1,4-diol

N,N'-fumaroyldi<(2R)-bornane-10,2-sultam>

Downstream raw materials:

C₂₀H₂₀O₆