Cyclobutanone, 3-(phenylmethyl)-

Base Information

• Chemical Name: Cyclobutanone, 3-(phenylmethyl)-
• CAS No.: 55262-02-7
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Mol file: 55262-02-7.mol

Synonyms:

Chemical Property of Cyclobutanone, 3-(phenylmethyl)-

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

3-Benzylcyclobutanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclobutanone, 3-(phenylmethyl)-

There total 5 articles about Cyclobutanone, 3-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

carbon monoxide (201230-82-2) + allyl bromide (106-95-6) + iodomethylbenzene (620-05-3) → 3-benzyl-cyclobutanone (55262-02-7)

Guidance literature:

allyl bromide; With [(η5-pentamethylcyclopentadienyl)2TiCl]; In tetrahydrofuran; at -35 ℃; for 0.0166667h;

iodomethylbenzene; With samarium diiodide; In tetrahydrofuran; at -35 - 20 ℃;

carbon monoxide; In pentane; at 45 ℃; for 12h; under 517.162 Torr; Further stages.;

DOI:10.1021/ja0158657

Reference yield: 78.0%

1-methylsulfinyl-1-methylthio-3-benzylcyclobutane (55262-01-6) → 3-benzyl-cyclobutanone (55262-02-7)

Guidance literature:

With sulfuric acid; In diethyl ether; 1.) room temperature, 1d, 2.) reflux, 7h;

DOI:10.1246/bcsj.57.1637

Reference yield:

allylbenzene (300-57-2,57807-91-7) → 3-benzyl-cyclobutanone (55262-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc/copper couple; trichlorophosphate / diethyl ether / Reflux

2: acetic acid; zinc / 7 h / 20 - 80 °C

With zinc/copper couple; acetic acid; zinc; trichlorophosphate; In diethyl ether;

DOI:10.1016/j.tet.2012.03.108

upstream raw materials:

1-methylsulfinyl-1-methylthio-3-benzylcyclobutane

carbon monoxide

allyl bromide

iodomethylbenzene

Downstream raw materials:

(R)-dihydro-4-(phenylmethyl)furan-2(3H)-one