2-[12-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-dodeca-2,7-diynyloxy]-tetrahydro-pyran

Base Information

Chemical Name:2-[12-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-dodeca-2,7-diynyloxy]-tetrahydro-pyran
CAS No.:118647-24-8
Molecular Formula:C₂₈H₄₀O₄
Molecular Weight:440.623
Hs Code.:

Synonyms:

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Chemical Property of 2-[12-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-dodeca-2,7-diynyloxy]-tetrahydro-pyran

Chemical Property:

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Technology Process of 2-[12-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-dodeca-2,7-diynyloxy]-tetrahydro-pyran

There total 10 articles about 2-[12-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-dodeca-2,7-diynyloxy]-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80810-60-2
1,4-dimethoxy-2,3,5-trimethyl-6-(tetrahydrofur-2-yl)benzene

: 118647-24-8
2-[12-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-dodeca-2,7-diynyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / 70percent perchloric acid, hydrogen / 5percent palladium-charcoal / acetic acid / 1.5 h / 70 °C

2: triethylamine / CH₂Cl₂ / 1 h / -5 °C

3: sodium iodide / acetone / 2 h / 50 °C

4: 1.) sodium amide, 2.) hexamethylphosphoramide / 1.) THF, 50 deg C, 1.5 h, 2.) room temperature, 1 h

5: toluene-p-sulphonic acid / methanol / 0.5 h / 70 °C

6: triethylamine / CH₂Cl₂ / 1 h / -5 °C

7: sodium iodide / acetone / 2 h / 50 °C

8: 1.) sodium amide / 1.) Et₂O, liquid ammonia, -50 deg C - -40 deg C, 60 min, 2.) -50 deg C - -40 deg C, 100 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; perchloric acid; hydrogen; toluene-4-sulfonic acid; sodium amide; triethylamine; sodium iodide; palladium on activated charcoal; In methanol; dichloromethane; acetic acid; acetone;

Reference yield:

: 80810-61-3
4-(2,5-dimethoxy-3,4,6-trimethylphenyl)butan-1-ol

: 118647-24-8
2-[12-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-dodeca-2,7-diynyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / CH₂Cl₂ / 1 h / -5 °C

2: sodium iodide / acetone / 2 h / 50 °C

3: 1.) sodium amide, 2.) hexamethylphosphoramide / 1.) THF, 50 deg C, 1.5 h, 2.) room temperature, 1 h

4: toluene-p-sulphonic acid / methanol / 0.5 h / 70 °C

5: triethylamine / CH₂Cl₂ / 1 h / -5 °C

6: sodium iodide / acetone / 2 h / 50 °C

7: 1.) sodium amide / 1.) Et₂O, liquid ammonia, -50 deg C - -40 deg C, 60 min, 2.) -50 deg C - -40 deg C, 100 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; toluene-4-sulfonic acid; sodium amide; triethylamine; sodium iodide; In methanol; dichloromethane; acetone;

Reference yield:

: Methanesulfonic acid 4-(2,5-dimethoxy-3,4,6-trimethyl-phenyl)-butyl ester

: 118647-24-8
2-[12-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-dodeca-2,7-diynyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 6 steps

1: sodium iodide / acetone / 2 h / 50 °C

2: 1.) sodium amide, 2.) hexamethylphosphoramide / 1.) THF, 50 deg C, 1.5 h, 2.) room temperature, 1 h

3: toluene-p-sulphonic acid / methanol / 0.5 h / 70 °C

4: triethylamine / CH₂Cl₂ / 1 h / -5 °C

5: sodium iodide / acetone / 2 h / 50 °C

6: 1.) sodium amide / 1.) Et₂O, liquid ammonia, -50 deg C - -40 deg C, 60 min, 2.) -50 deg C - -40 deg C, 100 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; toluene-4-sulfonic acid; sodium amide; triethylamine; sodium iodide; In methanol; dichloromethane; acetone;