1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester
CAS No.:1268680-66-5
Molecular Formula:C₃₀H₃₂Cl₂F₂N₂O₄
Molecular Weight:593.498
Hs Code.:

1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester

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Chemical Property of 1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester

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Technology Process of 1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester

There total 9 articles about 1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98946-18-0
tert-Butyl 2,2,2-trichloroacetimidate

: 1268680-63-2
1-(6-carboxymethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester

: 1268680-66-5
1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; cyclohexene; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2014.03.039

Reference yield:

: 1268684-02-1
C₂₃H₂₈ClFN₂O₂Si

: 1268680-66-5
1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: cyclohexene; dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 °C

1.2: 20 °C

2.1: N-Bromosuccinimide / acetonitrile / 8 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / 1,4-dioxane; water / 18 h / 100 °C

4.1: boron trifluoride diethyl etherate / dichloromethane; cyclohexene / 3 h / 20 °C

With potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; boron trifluoride diethyl etherate; cyclohexene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; cyclohexene; 3.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.03.039

Reference yield:

: 1268684-05-4
C₁₃H₁₅ClFIN₂

: 1268680-66-5
1-(6-tert-butoxycarbonylmethyl-3-chloro-2-fluoro-phenyl)-5-(3-chloro-4-fluoro-phenyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / 2 h / 20 °C

1.2: 1 h / 120 °C

2.1: palladium diacetate; triphenylphosphine; triethylamine / 20 h / 20 °C

3.1: cyclohexene; dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 °C

3.2: 20 °C

4.1: N-Bromosuccinimide / acetonitrile / 8 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / 1,4-dioxane; water / 18 h / 100 °C

6.1: boron trifluoride diethyl etherate / dichloromethane; cyclohexene / 3 h / 20 °C

With potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; boron trifluoride diethyl etherate; palladium diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; cyclohexene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; cyclohexene; 2.1: |Sonogashira Cross-Coupling / 5.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.03.039