Benzeneethanamine, a-(fluoromethyl)-N-[(4-methoxyphenyl)methyl]-, (S)-

Base Information

Chemical Name:Benzeneethanamine, a-(fluoromethyl)-N-[(4-methoxyphenyl)methyl]-, (S)-
CAS No.:132207-10-4
Molecular Formula:C₁₇H₂₀FNO
Molecular Weight:273.35
Hs Code.:

Synonyms:

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Chemical Property of Benzeneethanamine, a-(fluoromethyl)-N-[(4-methoxyphenyl)methyl]-, (S)-

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Technology Process of Benzeneethanamine, a-(fluoromethyl)-N-[(4-methoxyphenyl)methyl]-, (S)-

There total 6 articles about Benzeneethanamine, a-(fluoromethyl)-N-[(4-methoxyphenyl)methyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59490-36-7
(2S)-methyl 2--3-phenyl-1-propanoate

: 132207-10-4
(2S)-1-fluoro-2--3-phenyl-propane

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / lithium aluminium hydride / tetrahydrofuran / 18 h / Heating

2: 82 percent / thionylchloride, triethylamine / CH₂Cl₂ / 24 h / -15 °C

3: 84 percent / ruthenium(III)chloride hydrate, sodium periodate, water / acetonitrile / 3 h / Ambient temperature

4: 1. tetrabutylammonium fluoride, 2. 20percent H₂SO₄ / 1. THF, 1.5 h, RT, 2. ether, 2 h, RT

With ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; tetrabutyl ammonium fluoride; water; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo00009a045

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 132207-10-4
(2S)-1-fluoro-2--3-phenyl-propane

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / triethylamine / tetrahydrofuran / 5 h / Ambient temperature

2: 98 percent / lithium aluminium hydride / tetrahydrofuran / 18 h / Heating

3: 82 percent / thionylchloride, triethylamine / CH₂Cl₂ / 24 h / -15 °C

4: 84 percent / ruthenium(III)chloride hydrate, sodium periodate, water / acetonitrile / 3 h / Ambient temperature

5: 1. tetrabutylammonium fluoride, 2. 20percent H₂SO₄ / 1. THF, 1.5 h, RT, 2. ether, 2 h, RT

With ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; tetrabutyl ammonium fluoride; water; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo00009a045

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 132207-10-4
(2S)-1-fluoro-2--3-phenyl-propane

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / triethylamine / tetrahydrofuran / 5 h / Ambient temperature

2: 98 percent / lithium aluminium hydride / tetrahydrofuran / 18 h / Heating

3: 82 percent / thionylchloride, triethylamine / CH₂Cl₂ / 24 h / -15 °C

4: 84 percent / ruthenium(III)chloride hydrate, sodium periodate, water / acetonitrile / 3 h / Ambient temperature

5: 1. tetrabutylammonium fluoride, 2. 20percent H₂SO₄ / 1. THF, 1.5 h, RT, 2. ether, 2 h, RT

With ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; tetrabutyl ammonium fluoride; water; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo00009a045