2-(4-Methoxy-phenyl)-octahydro-thiochromene

Base Information

• Chemical Name: 2-(4-Methoxy-phenyl)-octahydro-thiochromene
• CAS No.: 73669-95-1
• Molecular Formula: C₁₆H₂₂OS
• Molecular Weight: 262.416
• Mol file: 73669-95-1.mol

Synonyms:

Chemical Property of 2-(4-Methoxy-phenyl)-octahydro-thiochromene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Methoxy-phenyl)-octahydro-thiochromene

There total 6 articles about 2-(4-Methoxy-phenyl)-octahydro-thiochromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(4-Methoxy-phenyl)-3,4,5,6,7,8-hexahydro-2H-thiochromene (113612-97-8) → 2α-(4-methoxyphenyl)-cis-1-thiadecalin (73669-95-1,113428-01-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 100 ℃; for 4h; under 38000 Torr;

DOI:10.1007/BF00476376

Reference yield: 45.0%

2-(4-Methoxyphenyl)cyclohexathiopyrylium Tetrafluoroborate → 2-(4-Methoxy-phenyl)-3,4,5,6,7,8-hexahydro-2H-thiochromene (113612-97-8) + 2α-(4-methoxyphenyl)-cis-1-thiadecalin (73669-95-1,113428-01-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 100 ℃; for 8h; under 76000.1 Torr; Yields of byproduct given;

DOI:10.1007/BF00476376

Reference yield: 26.0%

2-[3-(4-Methoxy-phenyl)-3-oxo-propyl]-cyclohexanone (73669-77-9) → Trifluoro-acetate2-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-thiochromenylium; (73669-87-1) + 2-(4-Methoxy-phenyl)-octahydro-thiochromene (73669-95-1)

Guidance literature:

With hydrogen sulfide; In trifluoroacetic acid; Yields of byproduct given; 1.) room temperature, overnight; 2.) reflux;

upstream raw materials:

2-(4-Methoxy-phenyl)-3,4,5,6,7,8-hexahydro-2H-thiochromene

2-[3-(4-Methoxy-phenyl)-3-oxo-propyl]-cyclohexanone

trifluoroacetic acid

Downstream raw materials:

(2R,4aR,8aR)-2-(4-Methoxy-phenyl)-octahydro-thiochromene 1,1-dioxide

(1S,2R,4aR,8aR)-2-(4-Methoxy-phenyl)-octahydro-thiochromene 1-oxide