73669-77-9Relevant academic research and scientific papers
Microwave-mediated facile synthesis of steroid-like 1,5-diketones from Mannich salts
Rao, H. Surya Prakash,Poonguzhali,Senthilkumar
, p. 937 - 942 (2008/09/17)
A facile synthesis of some diketones that fit into a steroid motif was achieved from Mannich salts and cyclic ketones under microwave irradiation. Copyright Taylor & Francis Group, LLC.
Orally active antimalarial 3-substituted trioxanes: New synthetic methodology and biological evaluation
Posner, Gary H.
, p. 940 - 951 (2007/10/03)
On the basis of a mechanistic understanding of the mode of action of artemisinin-like antimalarials, a series of structurally simple 3-aryl- 1,2,4-trioxanes 5 was designed and was prepared in three to five operations from commercial reactants. The 3-aryl group was attached in each case as a nucleophile. In an electronically complementary fashion, 3-(fluoroalkyl)- trioxanes 6 were prepared via attachment of electrophilic fluoroalkyl esters. Both in vitro and in vivo antimalarial evaluations of these new trioxanes showed 12β-methoxy-3-aryltrioxanes 5g, 5j, 5k, and 5l to be highly potent, with crystalline fluorobenzyl ether trioxane 5k especially potent even when administered to rodents orally. As shown by rearrangement of hexamethyl Dewar benzene into hexamethylbenzene, iron-induced degradation of some of these 3- aryltrioxanes 5 involves generation of high-valent iron oxo species that might kill malaria parasites.
REACTIONS OF "SEMICYCLIC" 1,5-DIKETONES WITH HYDROGEN SULFIDE AND TRIFLUOROACETIC ACID
Stolbova, T. V.,Klimenko, S. K.,Kharchenko, V. G.
, p. 170 - 173 (2007/10/02)
The reactions of known and new "semicyclic" 1,5-diketones with hydrogen sulfide and with trifluoroacetic acid were studied.It was shown that under the investigated conditions both 1-aryl- and 1,3-diaryl-substituted diketones form 3R-5R-2-thiabicycloalkane
