Technology Process of Propanedioic acid, [(2-azidophenyl)methylene]-, diethyl ester
There total 2 articles about Propanedioic acid, [(2-azidophenyl)methylene]-, diethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethyl malonate;
With
piperidine;
In
ethanol;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
2-azidobenzaldehyde;
In
ethanol;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/acs.joc.9b01946
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium azide; N,N,N,N,N,N-hexamethylphosphoric triamide / 20 - 25 °C
2: piperidine; acetic acid / ethanol / 2 h / 0 - 25 °C / Inert atmosphere; Darkness
With
piperidine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium azide; acetic acid;
In
ethanol;
2: |Knoevenagel Condensation;
DOI:10.1055/s-0036-1590861
- Guidance literature:
-
With
sodium sulfide;
In
methanol; water;
at 25 ℃;
pH=7.4;
Kinetics;
Inert atmosphere;
DOI:10.1021/acs.joc.9b01946
