Technology Process of 2-amino-6-chloronicotinic acid N-oxide
There total 4 articles about 2-amino-6-chloronicotinic acid N-oxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-amino-6-chloronicotinic acid methyl ester N-oxide;
With
sodium hydroxide;
In
methanol;
for 1h;
Reflux;
With
hydrogenchloride;
In
water;
at 0 ℃;
pH=4-5;
DOI:10.1021/jm401249c
- Guidance literature:
-
With
water; sodium hydroxide;
In
ethanol;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diethyl ether; toluene; methanol / 0.75 h / 0 °C / Inert atmosphere
2.1: dihydrogen peroxide; methyltrioxorhenium(VII) / water; ethanol / 24 h / 20 °C
3.1: sodium hydroxide / methanol / 1 h / Reflux
3.2: 0 °C / pH 4-5
With
dihydrogen peroxide; methyltrioxorhenium(VII); sodium hydroxide;
In
methanol; diethyl ether; ethanol; water; toluene;
DOI:10.1021/jm401249c
