Methyl 2-amino-6-chloronicotinate

Base Information

• Chemical Name: Methyl 2-amino-6-chloronicotinate
• CAS No.: 849805-25-0
• Molecular Formula: C7H7ClN2O2
• Molecular Weight: 186.598
• Hs Code.: 2933399090
• Mol file: 849805-25-0.mol

Synonyms:methyl 2-amino-6-chloro-3-pyridinecarboxylate;METHYL 2-AMINO-6-CHLORONICOTINATE;methyl 6-chloro-2-aminonicotinate;2-amino-6-chloro-nicotinic acid methyl ester;3-Pyridinecarboxylic acid,2-amino-6-chloro-,methyl ester;

Chemical Property of Methyl 2-amino-6-chloronicotinate

Chemical Property:

• Boiling Point: 289.2±35.0 °C(Predicted)
• PKA: 0.61±0.50(Predicted)
• PSA: 65.21000
• Density: 1.384±0.06 g/cm3(Predicted)
• LogP: 1.68500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

methyl2-amino-6-chloronicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-amino-6-chloronicotinate

There total 7 articles about Methyl 2-amino-6-chloronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-amino-6-chloronicotinic acid (58584-92-2) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-amino-6-chloropyridine-3-carboxylate (849805-25-0)

Guidance literature:

In methanol; diethyl ether; toluene; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/cmdc.201600180

Reference yield: 75.0%

methyl 2,6-dichloronicotinate (65515-28-8) → methyl 2-amino-6-chloropyridine-3-carboxylate (849805-25-0)

Guidance literature:

With ammonia; In 1,4-dioxane; at 80 - 90 ℃; for 216h;

Reference yield: 68.0%

methanol (67-56-1) + 2-amino-6-chloronicotinic acid (58584-92-2) → methyl 2-amino-6-chloropyridine-3-carboxylate (849805-25-0)

Guidance literature:

methanol; 2-amino-6-chloronicotinic acid; With sulfuric acid; at 0 - 70 ℃; for 5h;

With sodium hydrogencarbonate; In methanol; water;

upstream raw materials:

methanol

2-amino-6-chloronicotinic acid

methyl 2,6-dichloronicotinate

2,6-dichloropyridine-3-carboxylic acid

Downstream raw materials:

5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid

2-amino-6-[5-(3,5-bistrifluoromethyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-nicotinic acid methyl ester

5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester

6-[5-(3,5-bistrifluoromethyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bis(tert-butoxycarbonyl)amino-nicotinic acid methyl ester

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