2H-1-Benzopyran-2-one, 3-acetyl-6-methoxy-

Base Information

• Chemical Name: 2H-1-Benzopyran-2-one, 3-acetyl-6-methoxy-
• CAS No.: 13252-80-7
• Molecular Formula: C12H10O4
• Molecular Weight: 218.209
• Mol file: 13252-80-7.mol

Synonyms:6-methoxy-3-acetyl-2H-chromen-2-one;3-Acethyl-6-methoxycoumarine;3-Acetyl-6-methoxy-2H-chromen-2-one;3-acetyl-6-methoxy-2-oxochromene;3-Acetyl-6-methoxy-cumarin;3-acetyl-6-methoxy-coumarin;6-methoxy-3-acetylchromen-2-one;3-acetyl-6-methoxy-2H-1-benzopyran-2-one;

Chemical Property of 2H-1-Benzopyran-2-one, 3-acetyl-6-methoxy-

Chemical Property:

• PSA: 56.51000
• LogP: 2.00420

Purity/Quality:

98%min ^*data from raw suppliers

3-Acetyl-6-methoxy-2H-chromen-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-1-Benzopyran-2-one, 3-acetyl-6-methoxy-

There total 10 articles about 2H-1-Benzopyran-2-one, 3-acetyl-6-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

O-Merrifield resin-bound 4-(2-acetoacetylethyl)phenol + 2-hydroxy-5-methoxybenzaldehyde (672-13-9) → 3-acetyl-6-methoxycoumarin (13252-80-7)

Guidance literature:

With piperidine; In ethanol; for 2.5h; Heating;

DOI:10.1055/s-2005-872142

Reference yield: 95.0%

2-hydroxy-5-methoxybenzaldehyde (672-13-9) + ethyl acetoacetate (141-97-9) → 3-acetyl-6-methoxycoumarin (13252-80-7)

Guidance literature:

With 1,5,7-triazabicyclo[4.4.0]dec-5-ene bound to polystyrene; at 30 ℃; for 15h; Neat (no solvent);

DOI:10.1002/ejoc.201001476

Reference yield: 95.0%

2-hydroxy-5-methoxybenzaldehyde (672-13-9) + acetoacetic acid methyl ester (105-45-3) → 3-acetyl-6-methoxycoumarin (13252-80-7)

Guidance literature:

With tert.-butylhydroperoxide; diphenylether; Fe₃O(biphenyl-4,4'-dicarboxylate)₃; In water; N,N-dimethyl-formamide; Heating;

DOI:10.1039/c5cy02191j

upstream raw materials:

2-hydroxy-5-methoxybenzaldehyde

ethyl acetoacetate

4,4-bis(ethylsulfanyl)but-3-en-2-one

acetoacetic acid methyl ester

Downstream raw materials:

8-methoxy-3-methyl-1-phenyl-1H-chromeno[4,3-c]pyrazol-4-one

6-methoxy-3-[1-(phenylhydrazono)-ethyl]-chromen-2-one

3-{1-[(E)-2-(3-chlorophenyl)hydrazono]ethyl}-6-methoxy-2H-chromen-2-one

diethyl 1-(3-chlorophenyl)-3-(6-methoxy-2-oxo-2H-chromene-3-yl)-1H-pyrazole-4,5-dicarboxylate