N-{2'-[5-(3,4-dichlorophenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-N-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide

Base Information

Chemical Name:N-{2'-[5-(3,4-dichlorophenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-N-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide
CAS No.:1421276-57-4
Molecular Formula:C₄₂H₅₉Cl₂N₅OS
Molecular Weight:752.935
Hs Code.:

N-{2'-[5-(3,4-dichlorophenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-N-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide

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Chemical Property of N-{2'-[5-(3,4-dichlorophenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-N-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide

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Technology Process of N-{2'-[5-(3,4-dichlorophenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-N-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide

There total 4 articles about N-{2'-[5-(3,4-dichlorophenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-N-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 6217-54-5
docosahexaenoic acid

: 1421276-56-3
N-{1-[5-(3,4-dichlorophenylamino)-[1,2,4]thiadiazol-3-yl]-propan-2-yl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine

: 1421276-57-4
N-{2'-[5-(3,4-dichlorophenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-N-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide

Guidance literature:: docosahexaenoic acid; With di(succinimido) carbonate; In acetonitrile; at 0 - 4 ℃; Inert atmosphere;

N-{1-[5-(3,4-dichlorophenylamino)-[1,2,4]thiadiazol-3-yl]-propan-2-yl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine; With triethylamine; In methanol; acetonitrile; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1134/S0012500812110031

Reference yield:

: 726160-27-6
N-(3,4-dichlorophenyl)-[3-(2-oxopropyl)[1,2,4]-thiadiazol-5-yl]amine

: 1421276-57-4
N-{2'-[5-(3,4-dichlorophenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-N-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 20 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 40 - 50 °C

3.1: di(succinimido) carbonate / acetonitrile / 0 - 4 °C / Inert atmosphere

3.2: 1.5 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; di(succinimido) carbonate; In methanol; acetonitrile;
DOI:10.1134/S0012500812110031

Reference yield:

: 36768-62-4
4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE

: 1421276-57-4
N-{2'-[5-(3,4-dichlorophenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-N-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 20 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 40 - 50 °C

3.1: di(succinimido) carbonate / acetonitrile / 0 - 4 °C / Inert atmosphere

3.2: 1.5 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; di(succinimido) carbonate; In methanol; acetonitrile;
DOI:10.1134/S0012500812110031