Alphagan P

Base Information

• Chemical Name: Alphagan P
• CAS No.: 1400635-36-0
• Molecular Formula: (x)C₄H₆O₆*C₁₁H₁₀BrN₅
• Molecular Weight: 442.23
• European Community (EC) Number: 629-848-5
• DSSTox Substance ID: DTXSID20426066
• Wikidata: Q27122452
• NCI Thesaurus Code: C47419
• RXCUI: 39171
• Mol file: 1400635-36-0.mol

Synonyms:5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline D-tartrate;5-bromo-6-(imidazolidinylideneamino)quinoxaline;5-bromo-6-(imidazolin-2-ylamino)quinoxaline;AGN 190342;AGN-190342;AGN190342;Alphagan;Alphagan P;brimonidine;brimonidine Purite;brimonidine tartrate;brimonidine tartrate (1:1);brimonidine tartrate (1:1), (S-(R*,R*))-isomer;brimonidine tartrate, (R-(R*,R*))-isomer;bromoxidine;mirvaso;Ratio Brimonidine;ratio-Brimonidine;Sanrosa;UK 14,304;UK 14,304 18;UK 14,304-18;UK 14,30418;UK 14,308;UK 14304;UK 14308;UK-14,304-18;UK-14,308;UK-14304;UK14,30418;UK14,308;UK14304

Chemical Property of Alphagan P

Chemical Property:

• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 5
• Exact Mass: 441.02840
• Heavy Atom Count: 27
• Complexity: 442

Purity/Quality:

99% ^*data from raw suppliers

BrimonidineL-tartarate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br.C(C(C(=O)O)O)(C(=O)O)O
• Isomeric SMILES: C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br.[C@H]([C@@H](C(=O)O)O)(C(=O)O)O
• Recent ClinicalTrials: Safety and Efficacy Study BRIMOCHOL? PF and Carbachol PF in Subjects With Emmetropic Phakic or Pseudophakic Presbyopia
• Recent EU Clinical Trials: A Multi-Center, Investigator-Masked, Randomized, Crossover, Equivalence Study of the Safety and Efficacy of Once Daily Brimonidine Tartrate 0.35% Ophthalmic
• Recent NIPH Clinical Trials: A phase I clinical pharmacology study of SJP-0125

Technology Process of Alphagan P

There total 3 articles about Alphagan P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tartaric acid (87-69-4,138508-61-9) + 5-bromo-6-(imidazolin-2-ylamino)-quinoxaline (59803-98-4) → tartrate salt of brimonidine + Brimonidine Tartrate 5-bromo-6-(2-imidazolidinylideneamino)quinoxaline L-tartrate (1400635-36-0)

Guidance literature:

In methanol;

Reference yield:

D-tartaric acid (147-71-7,138508-61-9) + 5-bromo-6-(imidazolin-2-ylamino)-quinoxaline (59803-98-4) → (5-bromoquinoxalin-6-yl)-(4,5-dihydro-1H-imidazol-2-yl)-amine L-tartrate (1400635-36-0,79570-19-7)

Guidance literature:

In methanol; water;

Reference yield:

6-amino-5-bromoquinoxaline hydrobromide (134892-45-8) → (5-bromoquinoxalin-6-yl)-(4,5-dihydro-1H-imidazol-2-yl)-amine L-tartrate (1400635-36-0,79570-19-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water / 2 h / 20 °C

2.1: benzene

2.2: Reflux

3.1: water; methanol

In methanol; water; benzene;

upstream raw materials:

tartaric acid

5-bromo-6-(imidazolin-2-ylamino)-quinoxaline

D-tartaric acid

6-amino-5-bromoquinoxaline hydrobromide

Downstream raw materials:

5-bromo-6-(imidazolin-2-ylamino)-quinoxaline

Refernces

• 1、 -. "Brimonidine Compositions for Treating Erythema". . . Retrieved 2009/04/24.