1-methyl-1H-indole-2-carboxylic acid benzyl-(3-p-tolyl-prop-2-ynyl)-amide

Base Information

Chemical Name:1-methyl-1H-indole-2-carboxylic acid benzyl-(3-p-tolyl-prop-2-ynyl)-amide
CAS No.:1273578-25-8
Molecular Formula:C₂₇H₂₄N₂O
Molecular Weight:392.5
Hs Code.:

Synonyms:

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Chemical Property of 1-methyl-1H-indole-2-carboxylic acid benzyl-(3-p-tolyl-prop-2-ynyl)-amide

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Technology Process of 1-methyl-1H-indole-2-carboxylic acid benzyl-(3-p-tolyl-prop-2-ynyl)-amide

There total 4 articles about 1-methyl-1H-indole-2-carboxylic acid benzyl-(3-p-tolyl-prop-2-ynyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1273578-50-9
N-benzyl-3-(4-methylphenyl)-2-propynylamine

: 118618-61-4
1-methyl-1H-indole-2-carbonyl chloride

: 1273578-25-8
1-methyl-1H-indole-2-carboxylic acid benzyl-(3-p-tolyl-prop-2-ynyl)-amide

Guidance literature:: N-benzyl-3-(4-methylphenyl)-2-propynylamine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

1-methyl-1H-indole-2-carbonyl chloride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1039/c0ob00728e

Reference yield:

: 100-46-9
benzylamine

: 1273578-25-8
1-methyl-1H-indole-2-carboxylic acid benzyl-(3-p-tolyl-prop-2-ynyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / 0 - 20 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 h / Inert atmosphere; Sealed tube; Heating

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 18 h / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine; In tetrahydrofuran; mineral oil; 2.1: Sonogashira reaction;
DOI:10.1039/c0ob00728e

Reference yield:

: 1197-51-9
N-propargylbenzylamine

: 1273578-25-8
1-methyl-1H-indole-2-carboxylic acid benzyl-(3-p-tolyl-prop-2-ynyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 h / Inert atmosphere; Sealed tube; Heating

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 18 h / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine; In tetrahydrofuran; mineral oil; 1.1: Sonogashira reaction;
DOI:10.1039/c0ob00728e