1-Methyl-1H-indole-2-carbonyl chloride

Base Information

Chemical Name:1-Methyl-1H-indole-2-carbonyl chloride
CAS No.:118618-61-4
Molecular Formula:C10H8 Cl N O
Molecular Weight:193.633
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90486652
Wikidata:Q82327941
Mol file:118618-61-4.mol

Synonyms:1-Methyl-1H-indole-2-carbonyl chloride;118618-61-4;1-methylindole-2-carbonyl chloride;1H-Indole-2-carbonylchloride,1-methyl-(9CI);SCHEMBL2322980;1-methylindole carbonyl chloride;DTXSID90486652;USATVDUBRWEFMO-UHFFFAOYSA-N;AKOS006318684;1-methyl-1H-2-indolecarbonyl chloride

Suppliers and Price of 1-Methyl-1H-indole-2-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
1-Methyl-1H-indole-2-carbonyl chloride 95+%
5g
$ 899.00

Matrix Scientific
1-Methyl-1H-indole-2-carbonyl chloride 95+%
1g
$ 347.00

Labseeker
1H-INDOLE-2-CARBONYLCHLORIDE,1-METHYL- 95
25g
$ 2750.00

Atlantic Research Chemicals
1-Methyl-1H-indole-2-carbonylchloride 95%
1gm:
$ 374.66

American Custom Chemicals Corporation
1H-INDOLE-2-CARBONYL CHLORIDE,1-METHYL- 95.00%
5G
$ 1739.43

American Custom Chemicals Corporation
1H-INDOLE-2-CARBONYL CHLORIDE,1-METHYL- 95.00%
1G
$ 958.65

Alichem
1-Methyl-1H-indole-2-carbonylchloride
500mg
$ 1910.46

Alichem
1-Methyl-1H-indole-2-carbonylchloride
100mg
$ 667.68

Total 16 raw suppliers

Chemical Property of 1-Methyl-1H-indole-2-carbonyl chloride

Chemical Property:

PSA：22.00000
LogP:2.55730
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:193.0294416
Heavy Atom Count:13
Complexity:219

Purity/Quality:

99%, ^*data from raw suppliers

1-Methyl-1H-indole-2-carbonyl chloride 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=CC=CC=C2C=C1C(=O)Cl

Technology Process of 1-Methyl-1H-indole-2-carbonyl chloride

There total 11 articles about 1-Methyl-1H-indole-2-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 16136-58-6
N-methyl-1H-indole-2-carboxylic acid

: 118618-61-4
1-methyl-1H-indole-2-carbonyl chloride

Guidance literature:: With thionyl chloride; In dichloromethane;
DOI:10.1021/jm900363q

Reference yield: 98.0%

: 79-37-8
oxalyl dichloride

: 16136-58-6
N-methyl-1H-indole-2-carboxylic acid

: 118618-61-4
1-methyl-1H-indole-2-carbonyl chloride

Guidance literature:: In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1202-04-6
indole-2-carboxylic acid methyl ester

: 118618-61-4
1-methyl-1H-indole-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 15.5 h / 0 °C

2: 1.96 g / KOH; H₂O / methanol / 16 h / Heating

3: SOCl₂ / dioxane / 6 h / Heating

With potassium hydroxide; thionyl chloride; water; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/ol052086c