TZ-9

Base Information

• Chemical Name: TZ-9
• CAS No.: 1002789-86-7
• Molecular Formula: C₁₇H₁₄N₆O₄
• Molecular Weight: 366.336
• Mol file: 1002789-86-7.mol

Synonyms:

Chemical Property of TZ-9

Chemical Property:

• Boiling Point: 675.9±65.0 °C(Predicted)
• PKA: 3.69±0.10(Predicted)
• Density: 1.477±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

SMI#9 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TZ-9

There total 7 articles about TZ-9 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-(bromomethyl)-N2-phenyl-1,3,5-triazine-2,4-diamine + 4-nitro-benzoic acid (62-23-7) → (4-amino-6-(phenylamino)[1,3,5]triazin-2-yl)methyl 4-nitrobenzoate (1002789-86-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h; Reflux;

DOI:10.1016/j.tetlet.2014.10.122

Reference yield: 67.0%

{4-amino-6-(phenylamino)-[1,3,5]triazin-2-yl}methanol (99056-81-2) + 4-nitro-benzoyl chloride (122-04-3) → (4-amino-6-(phenylamino)[1,3,5]triazin-2-yl)methyl 4-nitrobenzoate (1002789-86-7)

Guidance literature:

With triethylamine; In dichloromethane; at 40 ℃;

DOI:10.1016/j.tetlet.2014.10.122

Reference yield:

aniline (62-53-3) → (4-amino-6-(phenylamino)[1,3,5]triazin-2-yl)methyl 4-nitrobenzoate (1002789-86-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 18 h / 90 °C

1.2: sodium alkoxide / 3 h / 20 °C

2.1: methanol / 16 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Reflux

With hydrogenchloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.tetlet.2014.10.122

upstream raw materials:

{4-amino-6-(phenylamino)-[1,3,5]triazin-2-yl}methanol

4-nitro-benzoyl chloride

4-nitro-benzoic acid

1-carbamimidamido-N-(4-methoxyphenyl)methanimidamide