methyl 12α-hydroxy-3α-<(4-nitrophenyl)acetoxy>-5β-cholan-24-oate

Base Information

• Chemical Name: methyl 12α-hydroxy-3α-<(4-nitrophenyl)acetoxy>-5β-cholan-24-oate
• CAS No.: 169898-34-4
• Molecular Formula: C₃₃H₄₇NO₇
• Molecular Weight: 569.739
• Mol file: 169898-34-4.mol

Synonyms:

Chemical Property of methyl 12α-hydroxy-3α-<(4-nitrophenyl)acetoxy>-5β-cholan-24-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 12α-hydroxy-3α-<(4-nitrophenyl)acetoxy>-5β-cholan-24-oate

There total 1 articles about methyl 12α-hydroxy-3α-<(4-nitrophenyl)acetoxy>-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl deoxycholate (3245-38-3) + 4-nitrophenylacetyl chloride (50434-36-1) → methyl 12α-hydroxy-3α-<(4-nitrophenyl)acetoxy>-5β-cholan-24-oate (169898-34-4)

Guidance literature:

With pyridine; In toluene; at -4.2 ℃; for 17h;

Reference yield:

4-(4-nitrophenyl)butanoyl chloride (5600-63-5) + methyl 12α-hydroxy-3α-<(4-nitrophenyl)acetoxy>-5β-cholan-24-oate (169898-34-4) → methyl 3α-<(4-nitrophenyl)acetoxy>-12α-<4-(4-nitrophenyl)butanoyloxy>-5β-cholan-24-oate (169898-38-8)

Guidance literature:

With calcium hydride; N-benzyl-N,N,N-triethylammonium chloride; In toluene; at 100 ℃; for 15.5h; Yield given;

Reference yield:

3-(p-nitrophenyl)propanoyl chloride (107324-93-6) + methyl 12α-hydroxy-3α-<(4-nitrophenyl)acetoxy>-5β-cholan-24-oate (169898-34-4) → methyl 3α-<(4-nitrophenyl)acetoxy>-12α-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate (169898-37-7)

Guidance literature:

With calcium hydride; N-benzyl-N,N,N-triethylammonium chloride; In toluene; at 100 ℃; for 15.5h;

upstream raw materials:

methyl deoxycholate

4-nitrophenylacetyl chloride

Downstream raw materials:

methyl 3α-<(4-nitrophenyl)acetoxy>-12α-<4-(4-nitrophenyl)butanoyloxy>-5β-cholan-24-oate

methyl 3α-<(4-nitrophenyl)acetoxy>-12α-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate

(R)-4-{(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3-[2-(4-Amino-phenyl)-acetoxy]-12-[3-(4-amino-phenyl)-propionyloxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

(R)-4-{(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3-[2-(4-Amino-phenyl)-acetoxy]-12-[4-(4-amino-phenyl)-butyryloxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

Refernces