1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:183892-47-9
Molecular Formula:C₃₇H₅₄N₂O₆Si₂
Molecular Weight:679.017
Hs Code.:

1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:

Suppliers and Price of 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

There total 5 articles about 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139925-90-9
1-[(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 183892-47-9
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / dimethylformamide / 24 h / 25 °C

2: 80percent aq. AcOH / tetrahydrofuran / 24 h / 25 °C

3: 95 percent / trichloroacetic anhydride, DMSO, Et₃N / CH₂Cl₂ / 0.5 h / -70 °C

4: 2.) trichloroacetic anhydride, DMSO / 1.) Et₂O/pentane, -78 deg C, 2 min, 2.) CH₂Cl₂, -70 deg C, 30 min

With 1H-imidazole; acetic acid; dimethyl sulfoxide; triethylamine; trichloroacetic acid anhydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790720

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 183892-47-9
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / dimethylformamide / 24 h / 25 °C

2: 80percent aq. AcOH / tetrahydrofuran / 24 h / 25 °C

3: 95 percent / trichloroacetic anhydride, DMSO, Et₃N / CH₂Cl₂ / 0.5 h / -70 °C

4: 2.) trichloroacetic anhydride, DMSO / 1.) Et₂O/pentane, -78 deg C, 2 min, 2.) CH₂Cl₂, -70 deg C, 30 min

With 1H-imidazole; acetic acid; dimethyl sulfoxide; triethylamine; trichloroacetic acid anhydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790720

Reference yield:

: 162052-67-7
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 183892-47-9
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / trichloroacetic anhydride, DMSO, Et₃N / CH₂Cl₂ / 0.5 h / -70 °C

2: 2.) trichloroacetic anhydride, DMSO / 1.) Et₂O/pentane, -78 deg C, 2 min, 2.) CH₂Cl₂, -70 deg C, 30 min

With dimethyl sulfoxide; triethylamine; trichloroacetic acid anhydride; In dichloromethane;
DOI:10.1002/hlca.19960790720