(E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(2-(1-(methoxycarbonyl)piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Base Information

Chemical Name:(E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(2-(1-(methoxycarbonyl)piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt
CAS No.:1430562-74-5
Molecular Formula:C₂HF₃O₂*C₃₇H₃₇ClFN₃O₈
Molecular Weight:820.191
Hs Code.:

(E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(2-(1-(methoxycarbonyl)piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

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Chemical Property of (E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(2-(1-(methoxycarbonyl)piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

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Technology Process of (E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(2-(1-(methoxycarbonyl)piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

There total 12 articles about (E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(2-(1-(methoxycarbonyl)piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219623-21-8
(E)-3-(6-acetyl-3-chloro-2-fluorophenyl)acrylic acid

: 1224444-35-2
tert-butyl 4-isocyanobenzoate

: 1430564-24-1
methyl 4-(2-(3,4-dihydroisoquinolin-5-yloxy)ethyl)piperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1430562-74-5
(E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(2-(1-(methoxycarbonyl)piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Guidance literature:: (E)-3-(6-acetyl-3-chloro-2-fluorophenyl)acrylic acid; tert-butyl 4-isocyanobenzoate; methyl 4-(2-(3,4-dihydroisoquinolin-5-yloxy)ethyl)piperidine-1-carboxylate; In ethanol; for 24h; Reflux;

trifluoroacetic acid; In dichloromethane;

Reference yield:

: 477721-50-9
tert-butyl 4-formamidobenzoate

: 1430562-74-5
(E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(2-(1-(methoxycarbonyl)piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trichlorophosphate / tetrahydrofuran / 24 h / 0 - 20 °C

2: ethanol / 24 h / Reflux

With triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; 2: |Ugi Condensation;

Reference yield:

: 18144-47-3
tert-butyl 4-aminobenzoate

: 1430562-74-5
(E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(2-(1-(methoxycarbonyl)piperidin-4-yl)ethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 4-methyl-morpholine / dichloromethane / 18 h / 0 °C

2: triethylamine; trichlorophosphate / tetrahydrofuran / 24 h / 0 - 20 °C

3: ethanol / 24 h / Reflux

With 4-methyl-morpholine; dmap; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; 3: |Ugi Condensation;