4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide

Base Information

Chemical Name:4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide
CAS No.:1638885-65-0
Molecular Formula:C₂₁H₁₅F₄N₅O₂S
Molecular Weight:481.41
Hs Code.:

4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide

Synonyms:

Suppliers and Price of 4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide

There total 9 articles about 4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.3%

: 573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

: 463-71-8
thiophosgene

: 4-[(1-cyano-2,2,4,4-tetradeuteratedcyclobutyl)amino]-2-fluoro-N-methylbenzamide

: 1638885-65-0
4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide

Guidance literature:: 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile; thiophosgene; 4-[(1-cyano-2,2,4,4-tetradeuteratedcyclobutyl)amino]-2-fluoro-N-methylbenzamide; In N,N-dimethyl acetamide; at 60 ℃; for 16h;

With hydrogenchloride; In methanol; N,N-dimethyl acetamide; water; for 1h; Reflux;

Reference yield:

: 915087-25-1
2-fluoro-N-methyl-4-amino-benzamide

: 1638885-65-0
4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: α-deuterated methyl ethyl-d5 ketone / 1,4-dioxane

2.1: N,N-dimethyl acetamide / 16 h / 60 °C

2.2: 1 h / Reflux

With α-deuterated methyl ethyl-d5 ketone; In 1,4-dioxane; N,N-dimethyl acetamide;

Reference yield:

: 573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

: 463-71-8
thiophosgene

: 4-((3,3,4,4-tetradeuterio-1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide

: 1638885-65-0
4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide

Guidance literature:: 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile; thiophosgene; 4-((3,3,4,4-tetradeuterio-1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide; In N,N-dimethyl acetamide; at 60 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In N,N-dimethyl acetamide; water; for 2h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2017.04.071