Butanoic acid, 3-oxo-, (1S)-1-phenylethyl ester

Base Information

• Chemical Name: Butanoic acid, 3-oxo-, (1S)-1-phenylethyl ester
• CAS No.: 132679-10-8
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.241
• Mol file: 132679-10-8.mol

Synonyms:

Chemical Property of Butanoic acid, 3-oxo-, (1S)-1-phenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 3-oxo-, (1S)-1-phenylethyl ester

There total 2 articles about Butanoic acid, 3-oxo-, (1S)-1-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylethyl acetoacetate (40552-84-9) → 1-phenylethyl 3-hydroxybutanoate (134080-50-5) + (R)-1-phenylethyl-(S)-3-hydroxybutanoate (134080-50-5) + (S)-1-phenylethyl acetoacetate (132679-10-8) + (R)-1-phenylethyl acetoacetate (123261-65-4)

Guidance literature:

With D-glucose; Bakers yeast; yeast extract; In water; dimethyl sulfoxide; Yield given. Yields of byproduct given. Title compound not separated from byproducts; 1) 24-25 deg C, 0.5 h, 2) RT, 16 h;

DOI:10.1021/jo00011a031

Reference yield:

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + 1-Phenylethanol (98-85-1,13323-81-4) → (S)-1-phenylethyl acetoacetate (132679-10-8) + (R)-1-phenylethyl acetoacetate (123261-65-4)

Guidance literature:

In di-isopropyl ether; for 120h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature; Amano AK lipase;

DOI:10.1016/0957-4166(96)00121-8

upstream raw materials:

1-phenylethyl acetoacetate

4-methyleneoxetan-2-one

1-Phenylethanol

Refernces

• 1、 Hudlicky, Tomas,Tsunoda, Toshiya,Gadamasetti, Kumar G.,Murry, Jerry A.,Keck, Gary E.. "Yeast-Mediated Resolution of β-Keto Esters of Prochiral Alcohols". . p. 3619 - 3623. Retrieved 2007/10/02.