2-Bromo-3-fluorobenzamide

Base Information

Chemical Name:2-Bromo-3-fluorobenzamide
CAS No.:132715-70-9
Molecular Formula:C7H5BrFNO
Molecular Weight:218.025
Hs Code.:
DSSTox Substance ID:DTXSID60576938
Wikidata:Q82466818

Synonyms:2-Bromo-3-fluorobenzamide;132715-70-9;Benzamide, 2-bromo-3-fluoro-;DTXSID60576938;MFCD13185360;AKOS017560780;F73472;A1-37822

Suppliers and Price of 2-Bromo-3-fluorobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Bromo-3-fluorobenzamide

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:216.95385
Heavy Atom Count:11
Complexity:165

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)F)Br)C(=O)N

Technology Process of 2-Bromo-3-fluorobenzamide

There total 9 articles about 2-Bromo-3-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 132715-69-6
2-bromo-3-fluoro-benzoic acid

: 132715-70-9
2-Bromo-3-fluorobenzamide

Guidance literature:: 2-bromo-3-fluoro-benzoic acid; With thionyl chloride; at 60 ℃; for 6h;

With ammonium hydroxide; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2022.128526

Reference yield:

: 656235-44-8
(2-cyano-6-fluorophenyl)boronic acid

: 132715-70-9
2-Bromo-3-fluorobenzamide

: C₇H₇BFNO₃

Guidance literature:: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; water; In acetonitrile; at 25 ℃; pH=5.0 - 6.5;
DOI:10.1021/jo035184p

Reference yield:

: 403-54-3
m-Fluorobenzonitrile

: 132715-70-9
2-Bromo-3-fluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium diisopropylamide / tetrahydrofuran; heptane; ethylbenzene / 1.25 h / cooling

2: hydrochloric acid / various solvents / 1 h / 0 - 23 °C

3: 1,3-dibromo-5,5-dimethylhydantoin; H₂O / acetonitrile / 25 °C / pH 5.0 - 6.5

With hydrogenchloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; water; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; various solvents; acetonitrile;
DOI:10.1021/jo035184p