TCO-PEG4-Acid

Base Information

• Chemical Name: TCO-PEG4-Acid
• CAS No.: 1802913-21-8
• Molecular Formula: C₂₀H₃₅NO₈
• Molecular Weight: 417.5
• Mol file: 1802913-21-8.mol

Synonyms:

Chemical Property of TCO-PEG4-Acid

Chemical Property:

• Solubility.: Soluble in DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

TCO-PEG4-acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: TCO-PEG4-acid is a click chemistry linker containing a TCO (trans-cycloctene) and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC. , TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-DA reaction. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of TCO-PEG4-Acid

There total 1 articles about TCO-PEG4-Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid (663921-15-1) + trans-4-cycloocten-yl 2,5-dioxo-1-pyrrolidinyl ester carbonic acid → C20H35NO8 (1802913-21-8)

Guidance literature:

With triethylamine; In dichloromethane; for 16h; Cooling with ice;

DOI:10.1021/bc500605g

Reference yield: 32.0%

C20H35NO8 (1802913-21-8) + C13H16N2O3*C7H8O3S → C33H49N3O10

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/cbic.202000556

upstream raw materials:

3-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid