α-amine-ω-propionic acid tetraethylene glycol

Base Information

• Chemical Name: α-amine-ω-propionic acid tetraethylene glycol
• CAS No.: 663921-15-1
• Molecular Formula: C11H23NO6
• Molecular Weight: 265.307
• Hs Code.: 2922499990
• Mol file: 663921-15-1.mol

Synonyms:AmbotzPEG1370;Amino-PEG4-acid;1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid;

Chemical Property of α-amine-ω-propionic acid tetraethylene glycol

Chemical Property:

• Boiling Point: 409.6±40.0 °C(Predicted)
• PKA: 4.28±0.10(Predicted)
• PSA: 100.24000
• Density: 1.134±0.06 g/cm3(Predicted)
• LogP: 0.18650
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

H2N-Dpeg(4)-COOH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Amino-PEG4-acid is a very popular PEG linker. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond, long PEG spacer increases reagent's solubility in aqueous media.
• Uses: H2N-Dpeg(4)-COOH, can be used in optical imaging of integrin αvβ3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers. Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis.

Technology Process of α-amine-ω-propionic acid tetraethylene glycol

There total 18 articles about α-amine-ω-propionic acid tetraethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid (1257063-35-6) → 3-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid (663921-15-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 16h; under 750.075 Torr;

DOI:10.1016/j.ejmech.2020.112574

Reference yield: 98.0%

benzyl (E)-3-oxo-1-phenyl-2,7,10,13,16-pentaoxa-4-azanonadec-17-en-19-oate → 3-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid (663921-15-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 18h;

DOI:10.1002/jlcr.3816

Reference yield: 94.0%

1-phenyl-5,8,11,14-tetraoxa-2-azaheptadecan-17-oic acid → 3-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid (663921-15-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 15h; under 760.051 Torr;

DOI:10.3184/174751916X14631433537513

upstream raw materials:

tert-butyl 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoate

Tetraethylene glycol

tert-butyl 3-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)propanoate

tert-butyl 1-(methanesulfonyloxy)-3,6,9,12-tetraoxapentadecan-15-oate

Downstream raw materials:

C₂H₃O₂^(1-)*C₅₁H₇₄NO₆⁽¹⁺⁾

3-[2-(2-{2-[2-(2,4-dinitrophenylamino)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid

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