1-Cyclobutylpiperazine

Base Information

• Chemical Name: 1-Cyclobutylpiperazine
• CAS No.: 132800-13-6
• Molecular Formula: C8H16N2
• Molecular Weight: 140.228
• Hs Code.: 2933599590
• European Community (EC) Number: 842-518-7
• DSSTox Substance ID: DTXSID101314512
• Nikkaji Number: J3.052.829H
• Mol file: 132800-13-6.mol

Synonyms:1-cyclobutylpiperazine

Chemical Property of 1-Cyclobutylpiperazine

Chemical Property:

• Boiling Point: 217℃
• PKA: 9.28±0.10(Predicted)
• Flash Point: 92℃
• PSA: 15.27000
• Density: 1.014
• LogP: 0.71080
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 140.131348519
• Heavy Atom Count: 10
• Complexity: 104

Purity/Quality:

97% ^*data from raw suppliers

1-Cyclobutylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C1)N2CCNCC2

Technology Process of 1-Cyclobutylpiperazine

There total 3 articles about 1-Cyclobutylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-cyclobutyl-piperazine dihydrochloride → 1-cyclobutyl-piperazine (132800-13-6)

Guidance literature:

With sodium hydroxide;

Reference yield: 86.6%

4-cyclobutyl-piperazine-1-carboxylic acid tert-butyl ester (485798-62-7) → 1-cyclobutyl-piperazine (132800-13-6)

Guidance literature:

4-cyclobutyl-piperazine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃;

With sodium hydroxide; In dichloromethane; water;

Reference yield: 74.7%

→ 1-cyclobutyl-piperazine (132800-13-6)

Guidance literature:

upstream raw materials:

4-cyclobutyl-piperazine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

benzyl 2-(4-cyclobutylpiperazine-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate

C₂₃H₂₇FN₆

C₂₉H₃₁F₆N₇

4-(4-cyclobutylpiperazine-1-carbonyl)benzaldehyde