485798-62-7Relevant articles and documents
Pyrazolo [3,4 - the b] pyridine and [...] composition preparation method and use of (by machine translation)
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Paragraph 0302; 0303; 0304; 0305, (2017/07/22)
The present invention provides a pyrazolo [3,4 - the b] pyridine and [...] compound of preparation and use, in particular, the present invention provides a following formula (I) compounds are shown, wherein the definition of each group as described in the specification. The compounds of the invention has excellent tyrosine kinase inhibiting activity, so can be used for preparing a series of treating diseases associated with the tyrosine kinase activity of the drug. (by machine translation)
A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates
Leonard, John,Blacker, A. John,Marsden, Stephen P.,Jones, Martin F.,Mulholland, Keith R.,Newton, Rebecca
, p. 1400 - 1410 (2015/11/02)
The use of the "borrowing hydrogen strategy" in the synthesis of a number of typical pharmaceutical intermediates has been investigated. The main aim of this work was to investigate the scope and limitations of current methodology using standard laboratory techniques in an industrial context. Some interesting and significant results were achieved across a diverse set of complex substrates; however several drawbacks with this approach were identified, such as the high loading, poor turnover, and susceptibility to substrate inactivation of the catalysts. These are areas which are highlighted for future investigation and improvements.
Carbamate/urea derivatives
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Paragraph 0170-0171, (2014/06/24)
The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.