Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl

Base Information

• Chemical Name: Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl
• CAS No.: 5174-87-8
• Molecular Formula: C11H10 N2 O
• Molecular Weight: 186.213
• Hs Code.: 2933990090
• Mol file: 5174-87-8.mol

Synonyms:Ketone,methyl 2-methyl-1,8-naphthyridin-3-yl (7CI,8CI);2-Methyl-3-acetyl-1,8-naphthyridine; 3-Acetyl-2-methyl-1,8-naphthyridine

Chemical Property of Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl

Chemical Property:

• Vapor Pressure: 0.000384mmHg at 25°C
• Melting Point: 146-147 °C
• Boiling Point: 317.5°Cat760mmHg
• PKA: 2.47±0.30(Predicted)
• Flash Point: 150.2°C
• PSA: 42.85000
• Density: 1.18g/cm³
• LogP: 2.14080

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl

There total 2 articles about Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Aminonicotinaldehyde (7521-41-7) + acetylacetone (123-54-6,81235-32-7) → 1-(2-methyl-1,8-naphthyridin-3-yl)ethan-1-one (5174-87-8)

Guidance literature:

With charcoal MgO; In neat (no solvent); at 49.84 ℃; for 1h; Temperature; Green chemistry;

DOI:10.1002/cctc.201402602

Reference yield:

→ 1-(2-methyl-1,8-naphthyridin-3-yl)ethan-1-one (5174-87-8)

Guidance literature:

DOI:10.1039/j39660000315

Reference yield: 96.0%

4-chlorobenzaldehyde (104-88-1) + 1-(2-methyl-1,8-naphthyridin-3-yl)ethan-1-one (5174-87-8) → (E)-3-(4-Chloro-phenyl)-1-(2-methyl-[1,8]naphthyridin-3-yl)-propenone

Guidance literature:

With potassium hydroxide; at 20 ℃; for 0.1h;

upstream raw materials:

2-Aminonicotinaldehyde

acetylacetone

Downstream raw materials:

(E)-1-(2-Methyl-[1,8]naphthyridin-3-yl)-3-p-tolyl-propenone

(E)-3-(4-Chloro-phenyl)-1-(2-methyl-[1,8]naphthyridin-3-yl)-propenone

(E)-1-(2-Methyl-[1,8]naphthyridin-3-yl)-3-(3-nitro-phenyl)-propenone

(E)-1-(2-Methyl-[1,8]naphthyridin-3-yl)-3-phenyl-propenone