methyl 4-(1'-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)spiro[cyclohexane-1,3'-indolin]-6'-yl)benzoate

Base Information

Chemical Name:methyl 4-(1'-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)spiro[cyclohexane-1,3'-indolin]-6'-yl)benzoate
CAS No.:1620581-04-5
Molecular Formula:C₃₈H₄₆N₂O₅S
Molecular Weight:642.86
Hs Code.:

Synonyms:

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Chemical Property of methyl 4-(1'-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)spiro[cyclohexane-1,3'-indolin]-6'-yl)benzoate

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Technology Process of methyl 4-(1'-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)spiro[cyclohexane-1,3'-indolin]-6'-yl)benzoate

There total 4 articles about methyl 4-(1'-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)spiro[cyclohexane-1,3'-indolin]-6'-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1620581-43-2
2-isobutyl-2-(2-methoxy-5-(spiro[cyclohexane-1,3'-indolin]-1'-ylsulfonyl)phenyl)-4-methylpentanenitrile

: 171364-80-0
methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1620581-04-5
methyl 4-(1'-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)spiro[cyclohexane-1,3'-indolin]-6'-yl)benzoate

Guidance literature:: With palladium diacetate; tert-butylammonium hexafluorophosphate(V); cesium fluoride; silver carbonate; N-acetylglycine; at 100 ℃; for 36h; regioselective reaction; Sealed tube;
DOI:10.1021/ja505737x

Reference yield:

: 1620581-27-2
C₁₇H₂₄ClNO₃S

: 1620581-04-5
methyl 4-(1'-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)spiro[cyclohexane-1,3'-indolin]-6'-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 23 °C

2: palladium diacetate; N-acetylglycine; silver carbonate; cesium fluoride; tert-butylammonium hexafluorophosphate(V) / 36 h / 100 °C / Sealed tube

With palladium diacetate; tert-butylammonium hexafluorophosphate(V); triethylamine; cesium fluoride; silver carbonate; N-acetylglycine; In dichloromethane;
DOI:10.1021/ja505737x

Reference yield:

: 7035-03-2
2-methoxy-benzeneacetonitrile

: 1620581-04-5
methyl 4-(1'-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)spiro[cyclohexane-1,3'-indolin]-6'-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 23 °C

2: chlorosulfonic acid / chloroform / 1.5 h / 0 - 23 °C

3: triethylamine / dichloromethane / 0 - 23 °C

4: palladium diacetate; N-acetylglycine; silver carbonate; cesium fluoride; tert-butylammonium hexafluorophosphate(V) / 36 h / 100 °C / Sealed tube

With chlorosulfonic acid; palladium diacetate; tert-butylammonium hexafluorophosphate(V); sodium hydride; triethylamine; cesium fluoride; silver carbonate; N-acetylglycine; In dichloromethane; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja505737x