{2-[5-(Benzoyl-hydrazono)-3-hydroxy-1-methyl-6-oxo-1,2,3,4,5,6-hexahydro-indol-3a-ylsulfanyl]-propionylamino}-acetic acid

Base Information

• Chemical Name: {2-[5-(Benzoyl-hydrazono)-3-hydroxy-1-methyl-6-oxo-1,2,3,4,5,6-hexahydro-indol-3a-ylsulfanyl]-propionylamino}-acetic acid
• CAS No.: 64728-93-4
• Molecular Formula: C₂₁H₂₄N₄O₆S
• Molecular Weight: 460.511
• Mol file: 64728-93-4.mol

Synonyms:

Chemical Property of {2-[5-(Benzoyl-hydrazono)-3-hydroxy-1-methyl-6-oxo-1,2,3,4,5,6-hexahydro-indol-3a-ylsulfanyl]-propionylamino}-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[5-(Benzoyl-hydrazono)-3-hydroxy-1-methyl-6-oxo-1,2,3,4,5,6-hexahydro-indol-3a-ylsulfanyl]-propionylamino}-acetic acid

There total 4 articles about {2-[5-(Benzoyl-hydrazono)-3-hydroxy-1-methyl-6-oxo-1,2,3,4,5,6-hexahydro-indol-3a-ylsulfanyl]-propionylamino}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoic acid hydrazide (613-94-5) + [2-((3R,3aR)-3-Hydroxy-1-methyl-5,6-dioxo-1,2,3,4,5,6-hexahydro-indol-3a-ylsulfanyl)-propionylamino]-acetic acid → {2-[5-(Benzoyl-hydrazono)-3-hydroxy-1-methyl-6-oxo-1,2,3,4,5,6-hexahydro-indol-3a-ylsulfanyl]-propionylamino}-acetic acid (64728-93-4)

Guidance literature:

With hydrogenchloride; In water; at 25 ℃; Yield given;

DOI:10.1248/cpb.29.1935

Reference yield:

N-(2-mercaptopropionyl)glycine (1953-02-2) → {2-[5-(Benzoyl-hydrazono)-3-hydroxy-1-methyl-6-oxo-1,2,3,4,5,6-hexahydro-indol-3a-ylsulfanyl]-propionylamino}-acetic acid (64728-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / H₂O / 0.5 h / 25 °C

2: HCl / H₂O / 25 °C

With hydrogenchloride; sodium hydroxide; In water;

DOI:10.1248/cpb.29.1935

Reference yield:

Epinephrine (329-65-7,51028-73-0) → {2-[5-(Benzoyl-hydrazono)-3-hydroxy-1-methyl-6-oxo-1,2,3,4,5,6-hexahydro-indol-3a-ylsulfanyl]-propionylamino}-acetic acid (64728-93-4)

Guidance literature:

Multi-step reaction with 3 steps

1: K₃Fe(CN)6 / acetic acid; H₂O / 0.08 h / 5 °C

2: NaOH / H₂O / 0.5 h / 25 °C

3: HCl / H₂O / 25 °C

With hydrogenchloride; sodium hydroxide; potassium hexacyanoferrate(III); In water; acetic acid;

DOI:10.1248/cpb.29.1935

upstream raw materials:

benzoic acid hydrazide

N-(2-mercaptopropionyl)glycine

Epinephrine

adrenochrome