1-{[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}butyl)phenyl]methyl}-2,4-imidazolidinedione acetic acid salt

Base Information

Chemical Name:1-{[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}butyl)phenyl]methyl}-2,4-imidazolidinedione acetic acid salt
CAS No.:457658-85-4
Molecular Formula:C₂H₄O₂*C₂₉H₄₁N₃O₆
Molecular Weight:587.714
Hs Code.:

1-{[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}butyl)phenyl]methyl}-2,4-imidazolidinedione acetic acid salt

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Chemical Property of 1-{[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}butyl)phenyl]methyl}-2,4-imidazolidinedione acetic acid salt

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Technology Process of 1-{[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}butyl)phenyl]methyl}-2,4-imidazolidinedione acetic acid salt

There total 10 articles about 1-{[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}butyl)phenyl]methyl}-2,4-imidazolidinedione acetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₅IN₂O₃

: 457658-85-4
1-{[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}butyl)phenyl]methyl}-2,4-imidazolidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: N,N-dimethyl-formamide

4: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

5: water / 75 °C

With hydrogenchloride; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064

Reference yield:

: 457656-19-8
C₁₁H₁₄INO₂

: 457658-85-4
1-{[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}butyl)phenyl]methyl}-2,4-imidazolidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / water

2: hydrogenchloride / water

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4: N,N-dimethyl-formamide

5: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

6: water / 75 °C

With hydrogenchloride; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide; 3: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064

Reference yield:

: 457656-48-3
1-[(3-iodophenyl)methyl]-2,4-imidazolidinedione

: 457658-85-4
1-{[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}butyl)phenyl]methyl}-2,4-imidazolidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: N,N-dimethyl-formamide

3: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

4: water / 75 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064