(3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride)

Base Information

• Chemical Name: (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride)
• CAS No.: 199188-97-1
• Molecular Formula: C₁₈H₁₈F₃NO₂
• Molecular Weight: 337.342
• Mol file: 199188-97-1.mol

Synonyms:

Chemical Property of (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-Formylfluoxetine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride)

There total 5 articles about (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

FLUOXETINE (54910-89-3,57226-07-0,100568-02-3,100568-03-4,59333-67-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)formamide (199188-97-1)

Guidance literature:

With cobalt(II) diacetate tetrahydrate; at 150 ℃; for 3h; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.201800253

Reference yield: 84.0%

fluoxetine hydrochloride + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)formamide (199188-97-1)

Guidance literature:

With cobalt(II) acetate; at 150 ℃; for 3h; Inert atmosphere; Sealed tube;

Reference yield: 78.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + Adofen (56296-78-7) → N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)formamide (199188-97-1)

Guidance literature:

With molybdenum (IV) sulfide; at 150 ℃; for 18h;

upstream raw materials:

FLUOXETINE

formyl acetic anhydride

N,N-dimethyl-formamide

Adofen

Refernces

• 1、 Yin, Jiawen,Zhang, Jingyu,Cai, Changqun,Deng, Guo-Jun,Gong, Hang. "Catalyst-Free Transamidation of Aromatic Amines with Formamide Derivatives and Tertiary Amides with Aliphatic Amines". supporting information. p. 387 - 392. Retrieved 2019/01/11.
• 2、 Ma, Juan,Zhang, Jingyu,Gong, Hang. "Mn(II)-Catalyzed N -Acylation of Amines". . p. 693 - 703. Retrieved 2019/01/23.