[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-chloro-pyridin-3-yl)-isoxazol-4-yl]-methanone

Base Information

• Chemical Name: [1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-chloro-pyridin-3-yl)-isoxazol-4-yl]-methanone
• CAS No.: 620535-26-4
• Molecular Formula: C₂₇H₂₅Cl₂F₆N₅O₃Si
• Molecular Weight: 680.509
• Mol file: 620535-26-4.mol

Synonyms:

Chemical Property of [1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-chloro-pyridin-3-yl)-isoxazol-4-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-chloro-pyridin-3-yl)-isoxazol-4-yl]-methanone

There total 5 articles about [1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-chloro-pyridin-3-yl)-isoxazol-4-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(azidomethyl)-3,5-bis(trifluoromethyl)benzene (620533-92-8) → [1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-chloro-pyridin-3-yl)-isoxazol-4-yl]-methanone (620535-26-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 87 percent / NaOEt / ethanol

2.1: 70 percent / PCl₅ / toluene

3.1: LiBH₄ / tetrahydrofuran

3.2: 91 percent / Dess-Martin periodinane / CH₂Cl₂

4.1: tetrahydrofuran

4.2: 88 percent / MnO₂ / toluene

5.1: Et₃N / diethyl ether

With lithium borohydride; phosphorus pentachloride; sodium ethanolate; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; toluene; 3.2: Dess-Martin oxidation;

DOI:10.3987/COM-05-S(T)64

Reference yield:

1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazole-4-carbaldehyde (620534-41-0) → [1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-chloro-pyridin-3-yl)-isoxazol-4-yl]-methanone (620535-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran

1.2: 88 percent / MnO₂ / toluene

2.1: Et₃N / diethyl ether

With triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.3987/COM-05-S(T)64

Reference yield:

1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (620534-09-0) → [1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-chloro-pyridin-3-yl)-isoxazol-4-yl]-methanone (620535-26-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: LiBH₄ / tetrahydrofuran

1.2: 91 percent / Dess-Martin periodinane / CH₂Cl₂

2.1: tetrahydrofuran

2.2: 88 percent / MnO₂ / toluene

3.1: Et₃N / diethyl ether

With lithium borohydride; triethylamine; In tetrahydrofuran; diethyl ether; 1.2: Dess-Martin oxidation;

DOI:10.3987/COM-05-S(T)64

upstream raw materials:

1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

1-(azidomethyl)-3,5-bis(trifluoromethyl)benzene

1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazole-4-carbaldehyde

1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester