(1R,2R,3S,5S)-3-(Benzyloxy-phenyl-phosphinoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester

Base Information

Chemical Name:(1R,2R,3S,5S)-3-(Benzyloxy-phenyl-phosphinoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester
CAS No.:335332-32-6
Molecular Formula:C₃₃H₄₈NO₇PSi
Molecular Weight:629.806
Hs Code.:

(1R,2R,3S,5S)-3-(Benzyloxy-phenyl-phosphinoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester

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Chemical Property of (1R,2R,3S,5S)-3-(Benzyloxy-phenyl-phosphinoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester

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Technology Process of (1R,2R,3S,5S)-3-(Benzyloxy-phenyl-phosphinoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester

There total 3 articles about (1R,2R,3S,5S)-3-(Benzyloxy-phenyl-phosphinoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53-21-4
(-)-cocaine hydrochloride

: 335332-32-6
(1R,2R,3S,5S)-3-(Benzyloxy-phenyl-phosphinoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.25M aq. HCl / Heating

2: NaOH; pyridine / 80 °C

3: LDA

With pyridine; hydrogenchloride; sodium hydroxide; lithium diisopropyl amide;
DOI:10.1016/S0960-894X(00)00659-4

Reference yield:

: 824-72-6
P,P-dichlorophenylphosphine oxide

: 335332-32-6
(1R,2R,3S,5S)-3-(Benzyloxy-phenyl-phosphinoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N

1.2: PCl₅ / CHCl₃

2.1: LDA

With triethylamine; lithium diisopropyl amide;
DOI:10.1016/S0960-894X(00)00659-4

Reference yield:

: 50972-25-3
C₁₃H₁₂ClO₂P

: 335332-30-4
(1R,2R,3S,5S)-3-Hydroxy-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester

: 335332-32-6
(1R,2R,3S,5S)-3-(Benzyloxy-phenyl-phosphinoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester

Guidance literature:: (1R,2R,3S,5S)-3-Hydroxy-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-(2-trimethylsilanyl-ethoxycarbonyl)-pentyl ester; With lithium diisopropyl amide;

C₁₃H₁₂ClO₂P;
DOI:10.1016/S0960-894X(00)00659-4