Technology Process of <3'',3'',4'',4''-(2)H4>-N(2)-acetylfolic acid
There total 7 articles about <3'',3'',4'',4''-(2)H4>-N(2)-acetylfolic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 55 percent / HOBt, DCC, DIEA / tetrahydrofuran / 48 h / -5 °C
2: 2.) Me2NH*BH3 / 1.) glacial acetic acid, r.t., 15 min, 2.) glacial acetic acid, r.t., 20 min; 60 deg C, 10 min
With
dimethylamine borane; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 2 h, 2.) ether, hexane, -78 deg C to r.t.
2: 55 percent / HOBt, DCC, DIEA / tetrahydrofuran / 48 h / -5 °C
3: 2.) Me2NH*BH3 / 1.) glacial acetic acid, r.t., 15 min, 2.) glacial acetic acid, r.t., 20 min; 60 deg C, 10 min
With
n-butyllithium; dimethylamine borane; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 78 percent / CH2Cl2 / 1 h / Ambient temperature
2: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 2 h, 2.) ether, hexane, -78 deg C to r.t.
3: 55 percent / HOBt, DCC, DIEA / tetrahydrofuran / 48 h / -5 °C
4: 2.) Me2NH*BH3 / 1.) glacial acetic acid, r.t., 15 min, 2.) glacial acetic acid, r.t., 20 min; 60 deg C, 10 min
With
n-butyllithium; dimethylamine borane; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; dichloromethane;
