[2-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-3,5-dioxo-[1,2,4]oxadiazolidin-4-yl]-acetic acid tert-butyl ester

Base Information

• Chemical Name: [2-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-3,5-dioxo-[1,2,4]oxadiazolidin-4-yl]-acetic acid tert-butyl ester
• CAS No.: 1026371-01-6
• Molecular Formula: C₃₇H₄₄F₃N₃O₇
• Molecular Weight: 699.767

Synonyms:

Chemical Property of [2-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-3,5-dioxo-[1,2,4]oxadiazolidin-4-yl]-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-3,5-dioxo-[1,2,4]oxadiazolidin-4-yl]-acetic acid tert-butyl ester

There total 7 articles about [2-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-3,5-dioxo-[1,2,4]oxadiazolidin-4-yl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → [2-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-3,5-dioxo-[1,2,4]oxadiazolidin-4-yl]-acetic acid tert-butyl ester (1026371-01-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: toluene; tetrahydrofuran / 48 h

5.1: DIBAL / diethyl ether / 0.5 h / -78 °C

6.1: TFA / CH₂Cl₂ / 8 h

7.1: tetrahydrofuran / 0.5 h / -5 °C

8.1: K₂CO₃

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction / 6.1: acidolysis / 7.1: Cyclization / 8.1: Alkylation;

DOI:10.1021/jm990476x

Reference yield:

4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole (174258-39-0) → [2-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-3,5-dioxo-[1,2,4]oxadiazolidin-4-yl]-acetic acid tert-butyl ester (1026371-01-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

2.1: NaH / toluene / 1 h

2.2: toluene; tetrahydrofuran / 48 h

3.1: DIBAL / diethyl ether / 0.5 h / -78 °C

4.1: TFA / CH₂Cl₂ / 8 h

5.1: tetrahydrofuran / 0.5 h / -5 °C

6.1: K₂CO₃

With sodium hydride; diisobutylaluminium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation / 3.1: Reduction / 4.1: acidolysis / 5.1: Cyclization / 6.1: Alkylation;

DOI:10.1021/jm990476x

Reference yield:

4,5-dimethyl-2-(4-trifluoromethylphenyl)-oxazole 3-oxide (475480-98-9) → [2-(3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-undec-2-enyl)-3,5-dioxo-[1,2,4]oxadiazolidin-4-yl]-acetic acid tert-butyl ester (1026371-01-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

2.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

3.1: NaH / toluene / 1 h

3.2: toluene; tetrahydrofuran / 48 h

4.1: DIBAL / diethyl ether / 0.5 h / -78 °C

5.1: TFA / CH₂Cl₂ / 8 h

6.1: tetrahydrofuran / 0.5 h / -5 °C

7.1: K₂CO₃

With sodium hydride; diisobutylaluminium hydride; potassium carbonate; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 1.1: Chlorination / 2.1: Alkylation / 3.1: Metallation / 3.2: Condensation / 4.1: Reduction / 5.1: acidolysis / 6.1: Cyclization / 7.1: Alkylation;

DOI:10.1021/jm990476x

upstream raw materials:

4-Trifluoromethylbenzaldehyde

4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

4,5-dimethyl-2-(4-trifluoromethylphenyl)-oxazole 3-oxide

1-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-nonan-1-one

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