Multi-step reaction with 7 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 °C
2: acetic acid; zinc / tetrahydrofuran; para-xylene / 4 h / 0 °C
3: pyridine / dichloromethane / 0 °C
4: pyridine hydrogenfluoride / tetrahydrofuran / 0 °C
5: N-iodo-succinimide; trifluorormethanesulfonic acid / dichloromethane / 4 h / -20 - 20 °C / Molecular sieve; Inert atmosphere
6: pyridine hydrogenfluoride / tetrahydrofuran / 0 °C
7: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / water; acetonitrile / 4 h
With
pyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; N-iodo-succinimide; trifluorormethanesulfonic acid; [bis(acetoxy)iodo]benzene; pyridine hydrogenfluoride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc;
In
tetrahydrofuran; dichloromethane; para-xylene; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c0cc04686h