17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal

Base Information

• Chemical Name: 17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal
• CAS No.: 496917-79-4
• Molecular Formula: C₇₄H₁₀₄O₇Si₃
• Molecular Weight: 1189.89

Synonyms:

Chemical Property of 17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal

There total 18 articles about 17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-tert-butyl-6-[3-(tert-butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-2,6,12,14,16-pentamethyl-heptadeca-1,5,7,9,15-pentaenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one (496918-12-8) → 17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal (496917-79-4)

Guidance literature:

With Dess-Martin periodane;

DOI:10.3987/com-02-s(m)17

Reference yield:

(E)-3-[(2R,5S,6S,9R)-2-tert-Butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-2-methyl-acrylic acid ethyl ester (146983-25-7) → 17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal (496917-79-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 82 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: 92 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 °C

3: toluene / 5 h / -78 °C

4: 99 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

5: 71 percent / (DHQD)2-PHAL; Ad-mix β; OsO4 / 2-methyl-propan-2-ol; H2O; toluene / 24 h

6: 94 percent / periodic acid / tetrahydrofuran / 2 h / 20 °C

7: 83 percent / toluene / 20 h / 85 °C

8: 82 percent / CrCl₂ / tetrahydrofuran / 1.5 h / 20 °C

9: 74 percent / Pd(PPh₃)4; aq. TlOH / tetrahydrofuran

10: 95 percent / Dess-Martin periodinane

With 2,6-dimethylpyridine; chromium dichloride; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; TlOH; oxalyl dichloride; diisobutylaluminium hydride; Dess-Martin periodane; dimethyl sulfoxide; periodic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol; 2: Swern oxidation / 5: Sharpless dihydroxylation / 8: Takai reaction / 9: Suzuki cross coupling / 10: Dess-Martin oxidation;

DOI:10.3987/com-02-s(m)17

Reference yield:

(2R,2R,4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(2-methylpropen-1-ol)cyclohex-1-ene-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-ol (497065-29-9) → 17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal (496917-79-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 92 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 °C

2: toluene / 5 h / -78 °C

3: 99 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

4: 71 percent / (DHQD)2-PHAL; Ad-mix β; OsO4 / 2-methyl-propan-2-ol; H2O; toluene / 24 h

5: 94 percent / periodic acid / tetrahydrofuran / 2 h / 20 °C

6: 83 percent / toluene / 20 h / 85 °C

7: 82 percent / CrCl₂ / tetrahydrofuran / 1.5 h / 20 °C

8: 74 percent / Pd(PPh₃)4; aq. TlOH / tetrahydrofuran

9: 95 percent / Dess-Martin periodinane

With 2,6-dimethylpyridine; chromium dichloride; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; TlOH; oxalyl dichloride; Dess-Martin periodane; dimethyl sulfoxide; periodic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol; 1: Swern oxidation / 4: Sharpless dihydroxylation / 7: Takai reaction / 8: Suzuki cross coupling / 9: Dess-Martin oxidation;

DOI:10.3987/com-02-s(m)17

upstream raw materials:

2-tert-butyl-6-[3-(tert-butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-2,6,12,14,16-pentamethyl-heptadeca-1,5,7,9,15-pentaenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one

(2S,4S,5S)-5-<(tert-Butyldiphenylsilyl)oxy>-7-dibromo-2,4-dimethyl-6-heptenol

(2'S,4S,4'S,5'S)-3-<5'-<(tert-Butyldiphenylsilyl)oxy>-7'-dibromo-2',4'-dimethylhept-6'-enoyl>-4-isopropyl-1,3-oxazolidin-2-one

(2R,2R,4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(2-methylpropen-1-ol)cyclohex-1-ene-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-ol

Downstream raw materials:

C₇₄H₁₀₄O₇Si₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 496917-79-4 17-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-15-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-2,4,6,12,16-pentamethyl-heptadeca-2,8,10,12,16-pentaenal

Send

Send

Metric Ton KG G Pound L ML

Send

Send